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Literature DB >> 2919417

Role for gamma-aminobutyric acid in selective vulnerability in gerbils.

L L Sternau¹, W D Lust, A J Ricci, R Ratcheson.

Abstract

We tested the efficacy of various putative neuroprotective agents in the gerbil model of delayed neuronal death. The selective loss of anterior CA1 neurons of the hippocampus 4 days after 5 minutes of bilateral ischemia was complete in greater than 90% of the gerbils examined. We tested 11 agents for their ability to protect against neuronal loss. Only those agents that were associated with the GABAergic system exhibited protection and only when administered before the ischemic insult. The possibility that delayed neuronal death is the result of a primary defect in inhibitory neurotransmission is considered.

Entities: Chemical Disease Gene

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Year: 1989 PMID： 2919417 DOI： 10.1161/01.str.20.2.281

Source DB: PubMed Journal: Stroke ISSN： 0039-2499 Impact factor: 7.914

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Cited

23 in total

Review 1. Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA.

Authors: L N Robin; M Kalloniatis
Journal: Doc Ophthalmol Date: 1992 Impact factor: 2.379

2. Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization.

Authors: Melissa H Kelley; Noriko Taguchi; Ardalan Ardeshiri; Masayuki Kuroiwa; Patricia D Hurn; Richard J Traystman; Paco S Herson
Journal: J Neurochem Date: 2008-09-18 Impact factor: 5.372

3. Restraint stress-induced alterations in the levels of biogenic amines, amino acids, and AChE activity in the hippocampus.

Authors: B S Rao; T R Raju
Journal: Neurochem Res Date: 2000-12 Impact factor: 3.996

10. Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.

Authors: M Shimizu-Sasamata; P Bosque-Hamilton; P L Huang; M A Moskowitz; E H Lo
Journal: J Neurosci Date: 1998-11-15 Impact factor: 6.167

Role for gamma-aminobutyric acid in selective vulnerability in gerbils.

Review 1. Interrelationship between retinal ischaemic damage and turnover and metabolism of putative amino acid neurotransmitters, glutamate and GABA.

2. Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization.

3. Restraint stress-induced alterations in the levels of biogenic amines, amino acids, and AChE activity in the hippocampus.

4. Estradiol alters only GAD67 mRNA levels in ischemic rat brain with no consequent effects on GABA.

5. The effect of chlormethiazole on neuronal damage in a model of transient focal ischaemia.

6. Long-term changes in gerbil brain neurotransmitter receptors following transient cerebral ischaemia.

7. Effect of nerve growth factor on delayed neuronal death after cerebral ischaemia.

8. Inhibition in postischemic rat hippocampus: GABA receptors, GABA release, and inhibitory postsynaptic potentials.

9. Neuroprotective activity of chlormethiazole following transient forebrain ischaemia in the gerbil.

10. Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene.