OBJECTIVE: BACKGROUND: : Breath VOCs have the potential to noninvasively diagnose cancer. METHODS: Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS: : CONCLUSION: : This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
OBJECTIVE: BACKGROUND: : Breath VOCs have the potential to noninvasively diagnose cancer. METHODS: Exhaled breath samples were collected using 2-L double-layered Nalophan bags, and were analyzed using selected-ion-flow-tube mass-spectrometry. Gold-standard test for comparison was endoscopy for luminal inspection and computed tomography (CT) to confirm cancer recurrence. Three studies were conducted: RESULTS: : CONCLUSION: : This study suggests the association of a single breath biomarker with the primary presence and recurrence of CRCa. Further multicenter validation studies are required to validate these findings.
Authors: Lisa Brusselmans; Lieselot Arnouts; Charissa Millevert; Joyce Vandersnickt; Jan P van Meerbeeck; Kevin Lamote Journal: Transl Lung Cancer Res Date: 2018-10
Authors: Sheraz R Markar; Tom Wiggins; Stefan Antonowicz; Sung-Tong Chin; Andrea Romano; Konstantin Nikolic; Benjamin Evans; David Cunningham; Muntzer Mughal; Jesper Lagergren; George B Hanna Journal: JAMA Oncol Date: 2018-07-01 Impact factor: 31.777