Elisabeth Svensson1,2, Victor W Henderson1,3,4, Szimonetta Szépligeti1, Morten Gersel Stokholm5, Tejs Ehlers Klug6, Henrik Toft Sørensen1,3, Per Borghammer5. 1. Department of Clinical Epidemiology,Institute of Clinical Medicine, Aarhus University Hospital, Aarhus, Denmark. 2. The Danish Clinical Registries, Denmark. 3. Department of Health Research & Policy, Stanford University, Stanford, California, USA. 4. Department of Neurology & Neurological Sciences, Stanford University, Stanford, California, USA. 5. Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus, Denmark. 6. Department of Otorhinolaryngology, Head & Neck Surgery, Aarhus University Hospital, Aarhus, Denmark.
Abstract
BACKGROUND: We hypothesized that tonsillectomy modifies the risk of PD. OBJECTIVES: To test the hypothesis in a nationwide population-based cohort study. METHODS: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow-up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders. RESULTS: We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76-1.19]; for > 20 years' follow-up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64-1.41]). CONCLUSION: Tonsillectomy is not associated with risk of PD, especially early-onset PD.
BACKGROUND: We hypothesized that tonsillectomy modifies the risk of PD. OBJECTIVES: To test the hypothesis in a nationwide population-based cohort study. METHODS: We used Danish medical registries to construct a cohort of all patients in Denmark with an operation code of tonsillectomy 1980-2010 (n = 195,169) and a matched age and sex general population comparison cohort (n = 975,845). Patients were followed until PD diagnosis, death, censoring, or end of follow-up 30 November 2013. Using Cox regression, we computed hazard ratios for PD and corresponding 95% confidence intervals, adjusting for age and sex by study design, and potential confounders. RESULTS: We identified 100 and 568 patients diagnosed with PD among the tonsillectomy and general population comparison cohort, respectively, finding similar risks of PD (adjusted hazard ratio = 0.95 [95% confidence interval: 0.76-1.19]; for > 20 years' follow-up (adjusted hazard ratio = 0.96 [95% confidence interval: 0.64-1.41]). CONCLUSION: Tonsillectomy is not associated with risk of PD, especially early-onset PD.
Authors: Timothy R Sampson; Justine W Debelius; Taren Thron; Stefan Janssen; Gauri G Shastri; Zehra Esra Ilhan; Collin Challis; Catherine E Schretter; Sandra Rocha; Viviana Gradinaru; Marie-Francoise Chesselet; Ali Keshavarzian; Kathleen M Shannon; Rosa Krajmalnik-Brown; Pernilla Wittung-Stafshede; Rob Knight; Sarkis K Mazmanian Journal: Cell Date: 2016-12-01 Impact factor: 41.582
Authors: Karen M Powers; Denise M Kay; Stewart A Factor; Cyrus P Zabetian; Donald S Higgins; Ali Samii; John G Nutt; Alida Griffith; Berta Leis; John W Roberts; Erica D Martinez; Jennifer S Montimurro; Harvey Checkoway; Haydeh Payami Journal: Mov Disord Date: 2008-01 Impact factor: 10.338