Haruo Fujino1,2, Honoka Shingaki2, Shugo Suwazono3, Yukihiko Ueda4, Chizu Wada5, Takahiro Nakayama6, Masanori P Takahashi7,8, Osamu Imura2, Tsuyoshi Matsumura9. 1. Department of Special Needs Education, Oita University, 700 Dannoharu, Oita, Japan, 870-1192. 2. Graduate School of Human Sciences, Osaka University, Osaka, Japan. 3. Department of Neurology, National Hospital Organization Okinawa Hospital, Okinawa, Japan. 4. Okinawa International University, Okinawa, Japan. 5. Department of Neurology, National Hospital Organization Akita National Hospital, Yurihonjo, Japan. 6. Department of Neurology, Yokohama Rosai Hospital, Yokohama, Japan. 7. Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Osaka, Japan. 8. Department of Neurology, Osaka University Graduate School of Medicine, Osaka, Japan. 9. Department of Neurology, National Hospital Organization Toneyama National Hospital, Osaka, Japan.
Abstract
INTRODUCTION: This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. METHODS: Sixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL. QoL was assessed by 2 domains of the Muscular Dystrophy Quality of Life Scale (Psychosocial Relationships and Physical Functioning and Health). RESULTS: More than half of the patients exhibited cognitive impairment in attention/working memory, executive function, processing speed, and visuoconstructive ability. The Psychosocial Relationships factor was associated with processing speed, attention/working memory, and apathy, whereas depression and fatigue were associated with 2 QoL domains. DISCUSSION: Our study identified specific cognitive impairments in DM1. Specific cognitive functions and psychological factors may be potential contributors to QoL. Muscle Nerve 57: 742-748, 2018.
INTRODUCTION: This study sought to clarify whether specific cognitive abilities are impaired in patients with myotonic dystrophy type 1 (DM1) as well as to investigate the relationships among quality of life (QoL), cognitive function, and psychological factors. METHODS: Sixty patients with DM1 were evaluated on cognitive functioning (abstract reasoning, attention/working memory, executive function, processing speed, and visuoconstructive ability), apathy, depression, excessive daytime sleepiness, fatigue, and QoL. QoL was assessed by 2 domains of the Muscular Dystrophy Quality of Life Scale (Psychosocial Relationships and Physical Functioning and Health). RESULTS: More than half of the patients exhibited cognitive impairment in attention/working memory, executive function, processing speed, and visuoconstructive ability. The Psychosocial Relationships factor was associated with processing speed, attention/working memory, and apathy, whereas depression and fatigue were associated with 2 QoL domains. DISCUSSION: Our study identified specific cognitive impairments in DM1. Specific cognitive functions and psychological factors may be potential contributors to QoL. Muscle Nerve 57: 742-748, 2018.
Authors: Jacob N Miller; Alison Kruger; David J Moser; Laurie Gutmann; Ellen van der Plas; Timothy R Koscik; Sarah A Cumming; Darren G Monckton; Peggy C Nopoulos Journal: Front Neurol Date: 2021-07-01 Impact factor: 4.003
Authors: Edward Callus; Enrico G Bertoldo; Maria Beretta; Sara Boveri; Rosanna Cardani; Barbara Fossati; Elisa Brigonzi; Giovanni Meola Journal: Front Neurol Date: 2018-09-19 Impact factor: 4.003