Literature DB >> 29192676

GOTcha: lncRNA-ACOD1 targets metabolism during viral infection.

Marah C Runtsch1, Luke Aj O'Neill1.   

Abstract

Long-noncoding RNAs (lncRNAs) are emerging as important regulators of cellular processes, but few have been functionally characterized in host-pathogen interactions. A recent report in Science demonstrates a mechanistic role for a novel lncRNA in directly binding an essential metabolic enzyme, glutamic-oxaloacetic transaminase (GOT2); this interaction benefits viral replication via alteration of host metabolism.

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Year:  2017        PMID: 29192676      PMCID: PMC5799814          DOI: 10.1038/cr.2017.153

Source DB:  PubMed          Journal:  Cell Res        ISSN: 1001-0602            Impact factor:   25.617


  13 in total

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  8 in total

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