Literature DB >> 29191367

Heterotypic Ubiquitin Chains: Seeing is Believing.

Alexandra Stolz1, Ivan Dikic2.   

Abstract

The biological diversity of ubiquitination resides in the multivalent nature of linkage-specific homotypic and heterotypic ubiquitin (Ub) chains. A recent publication by Yau et al. in Cell describes the development of K11/K48-bispecific antibodies and a physiological role for K11/K48 heterotypic chains in regulation of the cell cycle and clearance of aggregated proteins.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Keywords:  APC/C; Huntingtin (HTT); K11/K48 branched; heterotypic Ub chain; ubiquitin

Mesh：

Substances：

Year:  2017        PMID： 29191367     DOI： 10.1016/j.tcb.2017.11.005

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  6 in total

Review 1.  A20: A multifunctional tool for regulating immunity and preventing disease.

Authors:  Barbara A Malynn; Averil Ma
Journal:  Cell Immunol       Date:  2019-04-05       Impact factor: 4.868

2.  The Capture of a Disabled Proteasome Identifies Erg25 as a Substrate for Endoplasmic Reticulum Associated Degradation.

Authors:  Teresa M Buck; Xuemei Zeng; Pamela S Cantrell; Richard T Cattley; Zikri Hasanbasri; Megan E Yates; Diep Nguyen; Nathan A Yates; Jeffrey L Brodsky
Journal:  Mol Cell Proteomics       Date:  2020-08-31       Impact factor: 5.911

3.  Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X.

Authors:  Prajwal Paudel; Qi Zhang; Charles Leung; Harrison C Greenberg; Yusong Guo; Yi-Hsuan Chern; Aiping Dong; Yanjun Li; Masoud Vedadi; Zhihao Zhuang; Yufeng Tong
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-26       Impact factor: 11.205

Review 4.  Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code.

Authors:  David A Pérez Berrocal; Katharina F Witting; Huib Ovaa; Monique P C Mulder
Journal:  Front Chem       Date:  2020-01-22       Impact factor: 5.221

5.  Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation.

Authors:  Yanchang Li; Qiuyan Lan; Yuan Gao; Cong Xu; Zhongwei Xu; Yihao Wang; Lei Chang; Junzhu Wu; Zixin Deng; Fuchu He; Daniel Finley; Ping Xu
Journal:  iScience       Date:  2020-03-13

6.  Targeting Ubiquitin-Proteasome Pathway by Natural Products: Novel Therapeutic Strategy for Treatment of Neurodegenerative Diseases.

Authors:  Saeideh Momtaz; Zahra Memariani; Fardous F El-Senduny; Nima Sanadgol; Fereshteh Golab; Majid Katebi; Amir Hossein Abdolghaffari; Mohammad Hosein Farzaei; Mohammad Abdollahi
Journal:  Front Physiol       Date:  2020-04-28       Impact factor: 4.566
  6 in total

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