Literature DB >> 29191204

Correction to: Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

R A Moore1, H J McQuay2, J Tomaszewski3, G Raba4, D Tutunaru5, N Lietuviete6, J Galad7, L Hagymasy8, D Melka9, J Kotarski10, T Rechberger11, B Fülesdi12, A Nizzardo13, C Guerrero-Bayón14, S Cuadripani14, B Pizà-Vallespir14, M Bertolotti13.   

Abstract

CORRECTION: Following publication of the original article [1], the authors reported that additional file 10 contained a typing error in the table "Percentage of responders (≥50% max TOTPAR) over two, four, six and eight hours (single-dose phase) (ITT Population)". The table is to be read as follows.

Entities:  

Year:  2017        PMID: 29191204      PMCID: PMC5710074          DOI: 10.1186/s12871-017-0452-x

Source DB:  PubMed          Journal:  BMC Anesthesiol        ISSN: 1471-2253            Impact factor:   2.217


Correction

Following publication of the original article [1], the authors reported that additional file 10 contained a typing error in the table “Percentage of responders (≥50% max TOTPAR) over two, four, six and eight hours (single-dose phase) (ITT Population)”. The table is to be read as follows: TOTPAR: total pain relief; % max TOTPAR: percentage of the theoretical maximum possible TOTPAR; ITT: intention-to-treat; DKP/TRAM: dexketoprofen trometamol/tramadol hydrochloride 25 mg/75 mg; DKP: dexketoprofen trometamol 25 mg; TRAM: tramadol hydrochloride 100 mg; N: number of patients; n: number of patients with data. The ITT population included all patients randomised; response was defined as the achievement of at least 50% of the maximum possible TOTPAR within the respective treatment arm; TOTPAR was calculated as the time-weighted sum of the pain relief (PAR) scores; PAR was measured on a five-point verbal rating scale (VRS) (0 = none, 1 = slight, 2 = moderate, 3 = good, 4 = complete); the percentage of PAR responders was analysed using a chi-square test.
DKP/TRAM(N = 152)DKP (N = 151)TRAM (N = 150)Placebo (N = 153)
TOTPAR2 Responder, n (%)91 (60)69 (46)58 (39)50 (33)
Non-Responder, n (%)60 (40)82 (54)91 (61)103 (67)
Treatment comparisons p-value
DKP/TRAM vs. DKP0.011
DKP/TRAM vs. TRAM<0.001
DKP vs. Placebo0.020
TRAM vs. Placebo0.258
TOTPAR4 Responder, n (%)99 (65)80 (53)65 (43)49 (32)
Non-Responder, n (%)52 (34)71 (47)84 (56)104 (68)
Treatment comparisons p-value
DKP/TRAM vs. DKP0.026
DKP/TRAM vs. TRAM<0.001
DKP vs. Placebo<0.001
TRAM vs. Placebo0.038
TOTPAR6 Responder, n (%)105 (69)72 (48)64 (43)49 (32)
Non-Responder, n (%)46 (30)79 (52)85 (57)104 (68)
Treatment comparisons p-value
DKP/TRAM vs. DKP<0.001
DKP/TRAM vs. TRAM<0.001
DKP vs. Placebo0.005
TRAM vs. Placebo0.050
TOTPAR8 Responder, n (%)100 (66)72 (48)66 (44)47 (31)
Non-Responder, n (%)51 (34)79 (52)83 (55)106 (69)
Treatment comparisons p-value
DKP/TRAM vs. DKP0.001
DKP/TRAM vs. TRAM<0.001
DKP vs. Placebo0.002
TRAM vs. Placebo0.015
  1 in total

1.  Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

Authors:  R A Moore; H J McQuay; J Tomaszewski; G Raba; D Tutunaru; N Lietuviete; J Galad; L Hagymasy; D Melka; J Kotarski; T Rechberger; B Fülesdi; A Nizzardo; C Guerrero-Bayón; S Cuadripani; B Pizà-Vallespir; M Bertolotti
Journal:  BMC Anesthesiol       Date:  2016-01-22       Impact factor: 2.217

  1 in total

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