Lihua Gu1, Jiu Chen2, Lijuan Gao1, Hao Shu1, Zan Wang1, Duan Liu1, Yanna Yan3, Shijiang Li4, Zhijun Zhang5. 1. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China. 2. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China. Electronic address: ericcst@aliyun.com. 3. Department of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China. 4. Department of Biophysics, Medical College of Wisconsin, Milwaukee, WI, USA. 5. Department of Neurology, Affiliated ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu Province, China; Department of Psychology, Xinxiang Medical University, Xinxiang, Henan 453003, China. Electronic address: janemengzhang@vip.163.com.
Abstract
OBJECTIVES: The study aimed to investigate and compare the effect of cognitive reserve (CR) on brain activation in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) patients during 0-back and 1-back tasks measured by event-related potential (ERP). METHODS: The study recorded 85 subjects (39 aMCI patients and 46 their matched controls) with a 64-channel electroencephalogram (EEG). Subjects performed 0- and 1-back tasks. RESULTS: Compared to HC, aMCI patients showed reduced accuracy, delayed mean correct response time (RT) and decreased P300 amplitude at central-parietal and parietal electrodes. A mediation analysis indicated that higher CR reduced neural inefficiency, which might be associated with better task performance in HC. However, no correlation was detected between CR and neural inefficiency in aMCI patients, whereas higher CR was still related to enhanced accuracy and prolonged RT in aMCI patients. CONCLUSIONS: The present study reported that higher CR could contribute to better task performance via down-regulating neural inefficiency in HC. In addition, higher CR might modulate attention processes in aMCI via a way distinct from that in HC, and eventually result in better task performance. SIGNIFICANCE: The study provided evidence for that improving CR might lower cognitive impairment of healthy elderly and aMCI patients.
OBJECTIVES: The study aimed to investigate and compare the effect of cognitive reserve (CR) on brain activation in healthy controls (HC) and amnestic mild cognitive impairment (aMCI) patients during 0-back and 1-back tasks measured by event-related potential (ERP). METHODS: The study recorded 85 subjects (39 aMCI patients and 46 their matched controls) with a 64-channel electroencephalogram (EEG). Subjects performed 0- and 1-back tasks. RESULTS: Compared to HC, aMCI patients showed reduced accuracy, delayed mean correct response time (RT) and decreased P300 amplitude at central-parietal and parietal electrodes. A mediation analysis indicated that higher CR reduced neural inefficiency, which might be associated with better task performance in HC. However, no correlation was detected between CR and neural inefficiency in aMCI patients, whereas higher CR was still related to enhanced accuracy and prolonged RT in aMCI patients. CONCLUSIONS: The present study reported that higher CR could contribute to better task performance via down-regulating neural inefficiency in HC. In addition, higher CR might modulate attention processes in aMCI via a way distinct from that in HC, and eventually result in better task performance. SIGNIFICANCE: The study provided evidence for that improving CR might lower cognitive impairment of healthy elderly and aMCI patients.
Authors: Julie Gonneaud; Brigitte Landeau; Sophie Dautricourt; Vince D Calhoun; Robin de Flores; Géraldine Poisnel; Salma Bougacha; Valentin Ourry; Edelweiss Touron; Elizabeth Kuhn; Harriet Demintz-King; Natalie L Marchant; Denis Vivien; Vincent de la Sayette; Antoine Lutz; Gaël Chételat Journal: Alzheimers Res Ther Date: 2022-05-23 Impact factor: 8.823