| Literature DB >> 29189157 |
Dominik Szwajgier1, Ewa Baranowska-Wojcik1, Kamila Borowiec1.
Abstract
Numerous authors have provided evidence regarding the beneficial effects of phenolic acids and their derivatives against Alzheimer's disease (AD). In this review, the role of phenolic acids as inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) is discussed, including the structure-activity relationship. In addition, the inhibitory effect of phenolic acids on the formation of amyloid β-peptide (Aβ) fibrils is presented. We also cover the in vitro, ex vivo, and in vivo studies concerning the prevention and treatment of the cognitive enhancement. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Alzheimer's disease; acetylcholinesterase; amyloid β-peptide; benzoic acid; butyrylcholinesterase; cinnamic acid; cognition.
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Year: 2018 PMID： 29189157 DOI： 10.2174/1567205014666171128102557
Source DB: PubMed Journal: Curr Alzheimer Res ISSN： 1567-2050 Impact factor: 3.498