Literature DB >> 29189146

Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer´s Disease.

Lisbell D Estrada1, Luciana Oliveira-Cruz1, Daniel Cabrera2,3.   

Abstract

Alzheimer's disease is a neurodegenerative condition affecting millions of people worldwide. Alzheimer's symptoms include memory loss and cognitive decline. Pathologically, the hallmarks of Alzheimer´s are the presence of Amyloid beta-plaques, neurofibrillary tangles, and neuronal loss. Unfortunately, no cure is presently available and current treatments are only symptomatic. Transforming growth factor beta type I (TGF-β1) is a trophic factor involved in neuronal development and synaptic plasticity. Impairment of TGF-β1 signaling is associated with exacerbated Aβ deposition and neurofibrillary tangle formation, which increases neurodegeneration. Aging and chronic inflammation reduce the canonical TGF-β1/Smad signaling, facilitating cytotoxic activation of microglia and microgliamediated neurodegeneration This review gathers together evidence for a neuroprotective role of TGF-β in Alzheimer's disease. Restoring TGF-β1 signaling impairment may be a new pharmacological strategy Alzheimer's treatment. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Alzheimer´s disease; Smad signaling; Transforming growth factor-β1; amyloid-beta; microglia; neuroinflammation; neuroprotection; oligomers.

Mesh：

Substances：

Year:  2018        PMID： 29189146     DOI： 10.2174/1389203719666171129094937

Source DB:  PubMed          Journal:  Curr Protein Pept Sci        ISSN： 1389-2037            Impact factor:   3.272


  10 in total

1.  Association of childhood traumatization and neuropsychiatric outcomes with altered plasma micro RNA-levels.

Authors:  Sandra Van der Auwera; Sabine Ameling; Katharina Wittfeld; Enrique d'Harcourt Rowold; Matthias Nauck; Henry Völzke; Karsten Suhre; Hani Najafi-Shoushtari; Jaicy Methew; Vimal Ramachandran; Robin Bülow; Uwe Völker; Hans J Grabe
Journal:  Neuropsychopharmacology       Date:  2019-07-08       Impact factor: 7.853

2.  CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease.

Authors:  Shweta S Puntambekar; Miguel Moutinho; Peter Bor-Chian Lin; Vaishnavi Jadhav; Danika Tumbleson-Brink; Ananya Balaji; Martin Alvarado Benito; Guixiang Xu; Adrian Oblak; Cristian A Lasagna-Reeves; Gary E Landreth; Bruce T Lamb
Journal:  Mol Neurodegener       Date:  2022-06-28       Impact factor: 18.879

3.  Sirtuin 3 protects against anesthesia/surgery-induced cognitive decline in aged mice by suppressing hippocampal neuroinflammation.

Authors:  Qiang Liu; Yi-Man Sun; Hui Huang; Chen Chen; Jie Wan; Lin-Hui Ma; Yin-Ying Sun; Hui-Hui Miao; Yu-Qing Wu
Journal:  J Neuroinflammation       Date:  2021-02-04       Impact factor: 8.322

4.  Investigation of serum levels of orexin-A, transforming growth factor β, and leptin in patients with multiple sclerosis.

Authors:  Sepideh Moharami; Alireza Nourazarian; Masoud Nikanfar; Delara Laghousi; Behrouz Shademan; Omid Joodi Khanghah; Fatemeh Khaki-Khatibi
Journal:  J Clin Lab Anal       Date:  2021-12-11       Impact factor: 2.352

Review 5.  The Potential Role of Cytokines and Growth Factors in the Pathogenesis of Alzheimer's Disease.

Authors:  Gilbert Ogunmokun; Saikat Dewanjee; Pratik Chakraborty; Chandrasekhar Valupadas; Anupama Chaudhary; Viswakalyan Kolli; Uttpal Anand; Jayalakshmi Vallamkondu; Parul Goel; Hari Prasad Reddy Paluru; Kiran Dip Gill; P Hemachandra Reddy; Vincenzo De Feo; Ramesh Kandimalla
Journal:  Cells       Date:  2021-10-18       Impact factor: 6.600

Review 6.  Sepsis-Induced Brain Dysfunction: Pathogenesis, Diagnosis, and Treatment.

Authors:  Shangwen Pan; Zheng Lv; Rui Wang; Huaqing Shu; Shiying Yuan; Yuan Yu; You Shang
Journal:  Oxid Med Cell Longev       Date:  2022-08-24       Impact factor: 7.310

7.  Association of the inflammation-related proteome with dementia development at older age: results from a large, prospective, population-based cohort study.

Authors:  Kira Trares; Megha Bhardwaj; Laura Perna; Hannah Stocker; Agnese Petrera; Stefanie M Hauck; Konrad Beyreuther; Hermann Brenner; Ben Schöttker
Journal:  Alzheimers Res Ther       Date:  2022-09-09       Impact factor: 8.823

8.  Mendelian randomization integrating GWAS and mQTL data identified novel pleiotropic DNA methylation loci for neuropathology of Alzheimer's disease.

Authors:  Di Liu; Youxin Wang; Huiquan Jing; Qun Meng; Jingyun Yang
Journal:  Neurobiol Aging       Date:  2020-10-01       Impact factor: 4.673

Review 9.  TGF-β/Smad3 Signalling Modulates GABA Neurotransmission: Implications in Parkinson's Disease.

Authors:  Mª Dolores Muñoz; Nerea de la Fuente; Amelia Sánchez-Capelo
Journal:  Int J Mol Sci       Date:  2020-01-16       Impact factor: 5.923

10.  Transcriptomic characterization of tissues from patients and subsequent pathway analyses reveal biological pathways that are implicated in spastic ataxia.

Authors:  Andrea C Kakouri; Christina Votsi; Anastasis Oulas; Paschalis Nicolaou; Massimo Aureli; Giulia Lunghi; Maura Samarani; Giacomo M Compagnoni; Sabrina Salani; Alessio Di Fonzo; Thalis Christophides; George A Tanteles; Eleni Zamba-Papanicolaou; Marios Pantzaris; George M Spyrou; Kyproula Christodoulou
Journal:  Cell Biosci       Date:  2022-03-11       Impact factor: 7.133
  10 in total

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