Huijie Xing1, Huan Wang1, Baojian Wu1, Xingwang Zhang1.
Abstract
BACKGROUND: Thousands of bioactive compounds are identified and isolated from the medicinal plants every year, of which many possess significant health benefits. However, the overwhelming majority of entities suffer from poor water solubility and membrane permeability that impedes them approaching the clinical stage.
METHODS: Lipid nanoparticles have shown to be a versatile platform for advanced delivery of various therapeuticals, including the oral, topical and systemic routes. Lipid nanoparticles are able to significantly improve the oral bioavailability, pharmacokinetic profile, skin permeability, and ocular residence time of drugs, demonstrating considerable potential in pharmaceutical or medical practice.
RESULTS: This article profoundly reviews important applications of lipid nanoparticles in active natural medicines. Special concerns focus on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for their training in the oral, intravenous, percutaneous and ocular drug delivery.
CONCLUSION: The survey shows that lipid nanoparticles are promising vehicles for the delivery of various natural actives and may address some intractable problems associated with delivery thereof. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
BACKGROUND: Thousands of bioactive compounds are identified and isolated from the medicinal plants every year, of which many possess significant health benefits. However, the overwhelming majority of entities suffer from poor water solubility and membrane permeability that impedes them approaching the clinical stage.
METHODS: Lipid nanoparticles have shown to be a versatile platform for advanced delivery of various therapeuticals, including the oral, topical and systemic routes. Lipid nanoparticles are able to significantly improve the oral bioavailability, pharmacokinetic profile, skin permeability, and ocular residence time of drugs, demonstrating considerable potential in pharmaceutical or medical practice.
RESULTS: This article profoundly reviews important applications of lipid nanoparticles in active natural medicines. Special concerns focus on solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) for their training in the oral, intravenous, percutaneous and ocular drug delivery.
CONCLUSION: The survey shows that lipid nanoparticles are promising vehicles for the delivery of various natural actives and may address some intractable problems associated with delivery thereof. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.
Entities:
Keywords:
Lipid nanoparticles; drug delivery; nanostructured lipid carriers; natural medicines.; solid lipid nanoparticles
Year: 2017
PMID： 29189139 DOI： 10.2174/1381612824666171128105853
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116