T M N Otero1, D J Monlezun, K B Christopher, C A Camargo, S A Quraishi. 1. Sadeq A. Quraishi, MD, MHA, MMSc, Assistant Professor of Anaesthesia, Harvard Medical School, Staff Anesthetist and Intensivist, Massachusetts General Hospital, Department of Anesthesia, Critical Care, and Pain Medicine, 55 Fruit Street, GRJ 402, Boston, MA 02114, Tel: 617-643-5430, Fax: 617-724-6981, Email: squraishi@mgh.harvard.edu.
Abstract
OBJECTIVES: Elevated red cell distribution width (RDW) is associated with morbidity and mortality in community-dwelling individuals. Although RDW is traditionally used to diagnose anemia, it may also be a marker of systemic inflammation. Since vitamin D is a potent modulator of inflammatory cytokines our goal was to investigate whether 25-hydroxyvitamin D levels (25OHD) are associated with RDW in non-hospitalized adults. DESIGN: To investigate this association, we conducted a cross-sectional study. Stepwise multivariable linear and logistic regression models were used to assess the independent association of 25OHD with RDW. Elevated RDW was defined as >14.5%. SETTING: Nationwide sample of non-hospitalized adults within the United States. PARTICIPANTS: Individuals from the National Health and Nutrition Examination Survey from 2001-2006. RESULTS: 15,162 individuals comprised the analytic cohort. Mean 25OHD was 24.9 ng/mL (SE 0.4) and the prevalence of elevated RDW was 6.3%. Linear regression analysis, controlling for age, sex, race, mean corpuscular volume, albumin, and neutropenia, demonstrated that 25OHD was inversely associated with RDW (β=-0.01; 95%CI -0.01 to -0.01). Logistic regression analysis, controlling for the same covariates, also demonstrated an inverse association of 25OHD with elevated RDW (OR 0.96; 95%CI 0.94-0.99). Individuals with 25OHD <30 ng/mL were more likely to have elevated RDW (OR 1.65; 95%CI 1.13-2.40) compared to those individuals with levels ≥30ng/mL. CONCLUSIONS: In a nationwide sample of non-hospitalized adults within the United States, low 25OHD was associated with increased likelihood of elevated RDW. Further studies are needed to determine whether optimizing vitamin D status can reduce the prevalence of elevated RDW, and thereby reduce morbidity and mortality in the general population.
OBJECTIVES: Elevated red cell distribution width (RDW) is associated with morbidity and mortality in community-dwelling individuals. Although RDW is traditionally used to diagnose anemia, it may also be a marker of systemic inflammation. Since vitamin D is a potent modulator of inflammatory cytokines our goal was to investigate whether 25-hydroxyvitamin D levels (25OHD) are associated with RDW in non-hospitalized adults. DESIGN: To investigate this association, we conducted a cross-sectional study. Stepwise multivariable linear and logistic regression models were used to assess the independent association of 25OHD with RDW. Elevated RDW was defined as >14.5%. SETTING: Nationwide sample of non-hospitalized adults within the United States. PARTICIPANTS: Individuals from the National Health and Nutrition Examination Survey from 2001-2006. RESULTS: 15,162 individuals comprised the analytic cohort. Mean 25OHD was 24.9 ng/mL (SE 0.4) and the prevalence of elevated RDW was 6.3%. Linear regression analysis, controlling for age, sex, race, mean corpuscular volume, albumin, and neutropenia, demonstrated that 25OHD was inversely associated with RDW (β=-0.01; 95%CI -0.01 to -0.01). Logistic regression analysis, controlling for the same covariates, also demonstrated an inverse association of 25OHD with elevated RDW (OR 0.96; 95%CI 0.94-0.99). Individuals with 25OHD <30 ng/mL were more likely to have elevated RDW (OR 1.65; 95%CI 1.13-2.40) compared to those individuals with levels ≥30ng/mL. CONCLUSIONS: In a nationwide sample of non-hospitalized adults within the United States, low 25OHD was associated with increased likelihood of elevated RDW. Further studies are needed to determine whether optimizing vitamin D status can reduce the prevalence of elevated RDW, and thereby reduce morbidity and mortality in the general population.
Entities:
Keywords:
25OHD; RDW; Vitamin D; red cell distribution width
Authors: Stefanie S Schleithoff; Armin Zittermann; Gero Tenderich; Heiner K Berthold; Peter Stehle; Reiner Koerfer Journal: Am J Clin Nutr Date: 2006-04 Impact factor: 7.045
Authors: G Michael Felker; Larry A Allen; Stuart J Pocock; Linda K Shaw; John J V McMurray; Marc A Pfeffer; Karl Swedberg; Duolao Wang; Salim Yusuf; Eric L Michelson; Christopher B Granger Journal: J Am Coll Cardiol Date: 2007-06-18 Impact factor: 24.094