Takamitsu Nagashima1, Kentaro Yuda2,3,4, Takahiko Hayashi5,6,7. 1. Department of Ophthalmology, Saitamaika University Hospital, Saitama, Japan. 2. Department of Ophthalmology, Yokohama City University Hospital, Yokohama, Japan. 3. Department of Ophthalmology, Yokohama Minami Kyosai Hospital, 1-21-1, Mutsuura, Higashi, Kanazawa, Yokohama, 236-0037, Japan. 4. Kikuna Yuda Eye Clinic, Yokohama, Japan. 5. Department of Ophthalmology, Saitamaika University Hospital, Saitama, Japan. htakahiko-aikou@umin.ac.jp. 6. Department of Ophthalmology, Yokohama City University Hospital, Yokohama, Japan. htakahiko-aikou@umin.ac.jp. 7. Department of Ophthalmology, Yokohama Minami Kyosai Hospital, 1-21-1, Mutsuura, Higashi, Kanazawa, Yokohama, 236-0037, Japan. htakahiko-aikou@umin.ac.jp.
Abstract
PURPOSE: The present study aimed to evaluate the potential corneal endothelial cell toxicity of trypan blue (TB) and Brilliant Blue G (BBG), two dyes used to stain the anterior capsule in cataract surgery. METHODS: We conducted a single-center, prospective, randomized study in which 150 eyes of 117 patients were randomly divided into control (CT), TB, and BBG groups. Preoperative and postoperative (1, 3, and 6 months) values for corrected distance visual acuity (CDVA), corneal endothelial cell count, and central corneal thickness were compared among the three groups. RESULTS:A total of 111 eyes from 88 patients were completely analyzed. The CDVA (logarithm of the minimal angle of resolution) values in the CT, TB, and BBG groups 1 month after surgery were 0.001, 0.023, and 0.019, respectively. The corneal endothelial cell counts 6 months after surgery were 2711 ± 225, 2748 ± 251, and 2680 ± 284 cells/mm2, respectively. The central corneal thicknesses 6 months after surgery were 524.3 ± 35.5, 532.2 ± 36.1, and 531.4 ± 33.0 µm, respectively. There were no significant differences in CDVA, endothelial cell count, or central corneal thickness among the three groups during the follow-up period. CONCLUSIONS: Our findings indicate that neither TB nor BBG was associated with detectable toxicity to corneal endothelial cells during cataract surgery, even when injected directly into the anterior chamber. Additionally, BBG exhibited equivalent staining efficiency to TB.
RCT Entities:
PURPOSE: The present study aimed to evaluate the potential corneal endothelial cell toxicity of trypan blue (TB) and Brilliant Blue G (BBG), two dyes used to stain the anterior capsule in cataract surgery. METHODS: We conducted a single-center, prospective, randomized study in which 150 eyes of 117 patients were randomly divided into control (CT), TB, and BBG groups. Preoperative and postoperative (1, 3, and 6 months) values for corrected distance visual acuity (CDVA), corneal endothelial cell count, and central corneal thickness were compared among the three groups. RESULTS: A total of 111 eyes from 88 patients were completely analyzed. The CDVA (logarithm of the minimal angle of resolution) values in the CT, TB, and BBG groups 1 month after surgery were 0.001, 0.023, and 0.019, respectively. The corneal endothelial cell counts 6 months after surgery were 2711 ± 225, 2748 ± 251, and 2680 ± 284 cells/mm2, respectively. The central corneal thicknesses 6 months after surgery were 524.3 ± 35.5, 532.2 ± 36.1, and 531.4 ± 33.0 µm, respectively. There were no significant differences in CDVA, endothelial cell count, or central corneal thickness among the three groups during the follow-up period. CONCLUSIONS: Our findings indicate that neither TB nor BBG was associated with detectable toxicity to corneal endothelial cells during cataract surgery, even when injected directly into the anterior chamber. Additionally, BBG exhibited equivalent staining efficiency to TB.
Entities:
Keywords:
Anterior capsule; Brilliant Blue G; Cataract surgery; Toxicity; Trypan blue
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