Literature DB >> 29188093

Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile.

Chen Qiu1, Bianca Maceo Heilman1, Jari Kaipio2, Paul Donaldson1,3, Ehsan Vaghefi3,4.   

Abstract

Measuring the lens gradient refractive index (GRIN) accurately and reliably has proven an extremely challenging technical problem. A fully automated laser ray tracing (LRT) system was built to address this issue. The LRT system captures images of multiple laser projections before and after traversing through an ex vivo lens. These LRT images, combined with accurate measurements of the lens geometry, are used to calculate the lens GRIN profile. Mathematically, this is an ill-conditioned problem; hence, it is essential to apply biologically relevant constraints to produce a feasible solution. The lens GRIN measurements were compared with previously published data. Our GRIN retrieval algorithm produces fast and accurate measurements of the lens GRIN profile. Experiments to study the optics of physiologically perturbed lenses are the future direction of this research.

Keywords:  (110.2760) Gradient-index lenses; (140.0140) Lasers and laser optics; (170.0110) Imaging systems

Year:  2017        PMID： 29188093      PMCID： PMC5695943          DOI： 10.1364/BOE.8.004947

Source DB:  PubMed          Journal:  Biomed Opt Express        ISSN： 2156-7085            Impact factor:   3.732


  23 in total

1.  Accuracy of the reconstruction of the crystalline lens gradient index with optimization methods from ray tracing and Optical Coherence Tomography data.

Authors:  Alberto de Castro; Sergio Barbero; Sergio Ortiz; Susana Marcos
Journal:  Opt Express       Date:  2011-09-26       Impact factor: 3.894

2.  Tracing rays through graded-index media: a new method.

Authors:  A Sharma; D V Kumar; A K Ghatak
Journal:  Appl Opt       Date:  1982-03-15       Impact factor: 1.980

3.  Three-dimensional reconstruction of the crystalline lens gradient index distribution from OCT imaging.

Authors:  Alberto de Castro; Sergio Ortiz; Enrique Gambra; Damian Siedlecki; Susana Marcos
Journal:  Opt Express       Date:  2010-10-11       Impact factor: 3.894

4.  Analysis of Inhomogeneous Optical Systems by the Use of Ray Tracing. II. Three-dimensional Systems with Symmetry.

Authors:  G Beliakov; D Y Chan
Journal:  Appl Opt       Date:  1998-08-01       Impact factor: 1.980

Review 5.  Physiological properties of the normal lens.

Authors:  R T Mathias; J L Rae; G J Baldo
Journal:  Physiol Rev       Date:  1997-01       Impact factor: 37.312

Review 6.  The physiological optics of the lens.

Authors:  Paul J Donaldson; Angus C Grey; Bianca Maceo Heilman; Julie C Lim; Ehsan Vaghefi
Journal:  Prog Retin Eye Res       Date:  2016-09-14       Impact factor: 21.198

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Authors:  B K Pierscionek
Journal:  J Opt Soc Am A Opt Image Sci Vis       Date:  1993-09       Impact factor: 2.129

8.  Change with age of the refractive index gradient of the human ocular lens.

Authors:  R P Hemenger; L F Garner; C S Ooi
Journal:  Invest Ophthalmol Vis Sci       Date:  1995-03       Impact factor: 4.799

9.  Mefloquine effects on the lens suggest cooperative gating of gap junction channels.

Authors:  Francisco J Martinez-Wittinghan; Miduturu Srinivas; Caterina Sellitto; Thomas W White; Richard T Mathias
Journal:  J Membr Biol       Date:  2006-11-07       Impact factor: 1.843

10.  Characterization of the Effects of Hyperbaric Oxygen on the Biochemical and Optical Properties of the Bovine Lens.

Authors:  Julie C Lim; Ehsan Vaghefi; Bo Li; Mitchell G Nye-Wood; Paul J Donaldson
Journal:  Invest Ophthalmol Vis Sci       Date:  2016-04-01       Impact factor: 4.799
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  4 in total

1.  System for on- and off-axis volumetric OCT imaging and ray tracing aberrometry of the crystalline lens.

Authors:  Marco Ruggeri; Siobhan Williams; Bianca Maceo Heilman; Yue Yao; Yu-Cherng Chang; Ashik Mohamed; N Geetha Sravani; Heather Durkee; Cornelis Rowaan; Alex Gonzalez; Arthur Ho; Jean-Marie Parel; Fabrice Manns
Journal:  Biomed Opt Express       Date:  2018-07-24       Impact factor: 3.732

2.  Off-axis optical coherence tomography imaging of the crystalline lens to reconstruct the gradient refractive index using optical methods.

Authors:  Alberto de Castro; Judith Birkenfeld; Bianca Maceo Heilman; Marco Ruggeri; Esdras Arrieta; Jean-Marie Parel; Fabrice Manns; Susana Marcos
Journal:  Biomed Opt Express       Date:  2019-06-26       Impact factor: 3.732

Review 3.  From Presbyopia to Cataracts: A Critical Review on Dysfunctional Lens Syndrome.

Authors:  Joaquín Fernández; Manuel Rodríguez-Vallejo; Javier Martínez; Ana Tauste; David P Piñero
Journal:  J Ophthalmol       Date:  2018-06-27       Impact factor: 1.909

4.  Using the Lens Paradox to Optimize an In Vivo MRI-Based Optical Model of the Aging Human Crystalline Lens.

Authors:  Alyssa L Lie; Xingzheng Pan; Thomas W White; Paul J Donaldson; Ehsan Vaghefi
Journal:  Transl Vis Sci Technol       Date:  2020-07-28       Impact factor: 3.283
  4 in total

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