Federico Pessina1, Pierina Navarria2, Luca Cozzi3,4, Davide Franceschini2, Stefano Tomatis2, Elena Clerici2, Anna Maria Ascolese2, Fiorenza DE Rose2, Lorenzo Bello1, Giovanna Masci5, Armando Santoro4,5, Marta Scorsetti2,4. 1. Neurosurgical Oncology, Humanitas Cancer Center and Research Hospital, Rozzano-Milan, Italy. 2. Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Rozzano-Milan, Italy. 3. Radiotherapy and Radiosurgery, Humanitas Cancer Center and Research Hospital, Rozzano-Milan, Italy luca.cozzi@humanitas.it. 4. Department of Biomedical Sciences, Humanitas University, Rozzano-Milan, Italy. 5. Haematology and Oncology, Humanitas Cancer Center and Research Hospital, Rozzano-Milan, Italy.
Abstract
BACKGROUND/AIM: To appraise the outcome of limited brain metastasis (BMs) from HER2 breast cancer. PATIENTS AND METHODS: The study cohort included sixty-six patients Treatments consisted of surgery followed by radiotherapy (RT), or radiosurgery (SRS/HSRS) or whole brain radiotherapy (WBRT). RESULTS: Surgery followed by RT was performed in 25.8% of patients, SRS/HSRS alone in 48.5%, and WBRT alone in 25.7%. The median follow-up time was 23.4 months and 32.5 months for alive patients. Local recurrence occurred in 16 (24.2%) patients. The median, 1-, 2-, 3-year local control were (median not reached=nr), 87.5%, 71.2%, and 63.0%. The median 1-, 2-, 3-year overall survival were 30.7 months (95%CI: 18.9-42.6 months), 78.5%, 57.4%, 43.3%. Karnofsky Performance Scale (KPS), number of BMs, local treatment performed, the presence of extracranial (EC) metastases at the time of BMs diagnosis, and the administration of trastuzumab affected survival. CONCLUSION: HER2BC patients with good performance status, controlled EC disease and single BM had better outcome. In this long-term survivor patients, local BMs treatment can affect survival. Copyright
BACKGROUND/AIM: To appraise the outcome of limited brain metastasis (BMs) from HER2 breast cancer. PATIENTS AND METHODS: The study cohort included sixty-six patients Treatments consisted of surgery followed by radiotherapy (RT), or radiosurgery (SRS/HSRS) or whole brain radiotherapy (WBRT). RESULTS: Surgery followed by RT was performed in 25.8% of patients, SRS/HSRS alone in 48.5%, and WBRT alone in 25.7%. The median follow-up time was 23.4 months and 32.5 months for alive patients. Local recurrence occurred in 16 (24.2%) patients. The median, 1-, 2-, 3-year local control were (median not reached=nr), 87.5%, 71.2%, and 63.0%. The median 1-, 2-, 3-year overall survival were 30.7 months (95%CI: 18.9-42.6 months), 78.5%, 57.4%, 43.3%. Karnofsky Performance Scale (KPS), number of BMs, local treatment performed, the presence of extracranial (EC) metastases at the time of BMs diagnosis, and the administration of trastuzumab affected survival. CONCLUSION: HER2BC patients with good performance status, controlled EC disease and single BM had better outcome. In this long-term survivor patients, local BMs treatment can affect survival. Copyright
Authors: Kevin Armstrong; Jennifer Ward; Mary Dunne; Luke Rock; Jennifer Westrup; Christopher R Mascott; Pierre Thirion; Alina Mihaela Mihai Journal: Front Oncol Date: 2019-05-28 Impact factor: 6.244