Dominique Koensgen1, Ilma Besic1, Denis Gümbel2, Anne Kaul1, Martin Weiss3, Karoline Diesing1, Axel Kramer4, Sander Bekeschus5, Alexander Mustea1, Matthias B Stope6. 1. Department of Gynecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany. 2. Department of Trauma and Orthopaedic Surgery, University Medicine Greifswald, Greifswald, Germany. 3. Department of Obstetrics and Gynecology, University Hospital Tuebingen, Tuebingen, Germany. 4. Department of Hygiene and Environmental Medicine, University Medicine Greifswald, Greifswald, Germany. 5. ZIK Plasmatis, Leibniz-Institute for Plasma Science and Technology (INP Greifswald), Greifswald, Germany. 6. Department of Urology, University Medicine Greifswald, Greifswald, Germany matthias.stope@uni-greifswald.de.
Abstract
BACKGROUND/AIM: Ovarian cancer (OC) is a gynecologic tumor with poor prognosis. Despite radical cytoreductive surgery and platinum-based adjuvant systemic treatment, OC will relapse in the majority of the cases. Thus, cold atmospheric plasma (CAP), a highly reactive physical state bearing diverse biological activities being suited for anticancer therapy, may be a promising option in OC therapy. MATERIALS AND METHODS: OC cell lines were exposed either directly to the CAP or to cell culture medium previously exposed to CAP. Cell proliferation and cell motility was measured. RESULTS: The data demonstrated, that even a single application of a short-term CAP treatment led to an attenuation of OC cell growth and motility. Moreover, incubation with CAP-treated cell culture medium gave similar effects. Results were consistent in four OC cell lines. CONCLUSION: In summary, the CAP application in oncological surgery leads to strong anti-proliferative effects and opens up novel opportunities for the OC treatment. Copyright
BACKGROUND/AIM: Ovarian cancer (OC) is a gynecologic tumor with poor prognosis. Despite radical cytoreductive surgery and platinum-based adjuvant systemic treatment, OC will relapse in the majority of the cases. Thus, cold atmospheric plasma (CAP), a highly reactive physical state bearing diverse biological activities being suited for anticancer therapy, may be a promising option in OC therapy. MATERIALS AND METHODS: OC cell lines were exposed either directly to the CAP or to cell culture medium previously exposed to CAP. Cell proliferation and cell motility was measured. RESULTS: The data demonstrated, that even a single application of a short-term CAP treatment led to an attenuation of OC cell growth and motility. Moreover, incubation with CAP-treated cell culture medium gave similar effects. Results were consistent in four OC cell lines. CONCLUSION: In summary, the CAP application in oncological surgery leads to strong anti-proliferative effects and opens up novel opportunities for the OC treatment. Copyright
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