Literature DB >> 29186127

Mismatch repair prefers exons.

Dashiell J Massey1, Amnon Koren1.   

Abstract

A new analysis of cancer genomes identifies a decrease in the mutation burden of exons, but not introns, as compared to expectation. This difference can be explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification that marks exons.

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Year:  2017        PMID： 29186127     DOI： 10.1038/ng.3993

Source DB:  PubMed          Journal:  Nat Genet        ISSN： 1061-4036            Impact factor:   38.330


  13 in total

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