Sule Gunter1, Chanel Robinson1, Angela J Woodiwiss1, Gavin R Norton1, Hon-Chun Hsu1, Ahmed Solomon2, Linda Tsang3, Aletta M E Millen1, Patrick H Dessein4. 1. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 2. Rheumatology Division, Charlotte Maxeke Johannesburg Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. 3. Cardiovascular Pathophysiology and Genomics Research Unit, School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; and Rheumatology Division, Universitair Ziekenhuis Brussel (UZB), Belgium. 4. Cardiovascular Pathophysiology & Genomics Research Unit, School of Physiology, Faculty of Health Sciences, Univ. of the Witwatersrand, Johannesburg, South Africa; Rheumatology Div., Univ. Ziekenhuis Brussel (UZB); and Vrije Universiteit (VUB), Belgium.
Abstract
OBJECTIVES: Atherosclerotic cardiovascular disease risk is increased in rheumatoid arthritis (RA). Wave reflection occurs at arterial branching points, which are particularly prone to atherosclerosis. We explored the relationship of wave reflection with atherosclerosis in RA. METHODS: One hundred and sixty three RA patients (110 white, 31 Asian, 17 black and 5 of mixed ancestry) without cardiovascular disease participated. Arterial stiffness, wave reflection, pressure pulsatility, plaque in the extracranial carotid artery tree and the mean of the left and right common carotid arteries intima-thickness were determined. Associations were identified in multivariable regression models. RESULTS: One SD increase in reflected wave pressure (OR (95% CI) = 2.54 (1.41-4.44), p=0.001), reflection magnitude (OR (95% CI) = 1.84 (1.17-2.89), p=0.008), central pulse pressure (OR (95% CI) = 1.89 (1.12-3.22), p=0.02) and peripheral pulse pressure (OR (95% CI) = 2.09 (1.23-3.57), p=0.007) were associated with plaque. The association of wave reflection with plaque was independent of arterial stiffness and pressure pulsatility, and was present in both hypertensive and normotensive RA patients. In receiver operator characteristic curve analysis, the optimal cutoff value for reflected wave pressure in predicting plaque presence was 25 mmHg with a sensitivity, specificity, positive predictive value and negative predictive value of 45.2%, 89.3%, 78.6% and 66.2%, respectively; a reflected wave pressure of >25 mmHg was associated with plaque in univariate and adjusted analysis (p<0.0001 for both). Arterial function was not independently related to carotid intima-media thickness. CONCLUSIONS: Consideration and therapeutic targeting of wave reflection may improve cardiovascular disease prevention in RA.
OBJECTIVES:Atherosclerotic cardiovascular disease risk is increased in rheumatoid arthritis (RA). Wave reflection occurs at arterial branching points, which are particularly prone to atherosclerosis. We explored the relationship of wave reflection with atherosclerosis in RA. METHODS: One hundred and sixty three RApatients (110 white, 31 Asian, 17 black and 5 of mixed ancestry) without cardiovascular disease participated. Arterial stiffness, wave reflection, pressure pulsatility, plaque in the extracranial carotid artery tree and the mean of the left and right common carotid arteries intima-thickness were determined. Associations were identified in multivariable regression models. RESULTS: One SD increase in reflected wave pressure (OR (95% CI) = 2.54 (1.41-4.44), p=0.001), reflection magnitude (OR (95% CI) = 1.84 (1.17-2.89), p=0.008), central pulse pressure (OR (95% CI) = 1.89 (1.12-3.22), p=0.02) and peripheral pulse pressure (OR (95% CI) = 2.09 (1.23-3.57), p=0.007) were associated with plaque. The association of wave reflection with plaque was independent of arterial stiffness and pressure pulsatility, and was present in both hypertensive and normotensive RApatients. In receiver operator characteristic curve analysis, the optimal cutoff value for reflected wave pressure in predicting plaque presence was 25 mmHg with a sensitivity, specificity, positive predictive value and negative predictive value of 45.2%, 89.3%, 78.6% and 66.2%, respectively; a reflected wave pressure of >25 mmHg was associated with plaque in univariate and adjusted analysis (p<0.0001 for both). Arterial function was not independently related to carotid intima-media thickness. CONCLUSIONS: Consideration and therapeutic targeting of wave reflection may improve cardiovascular disease prevention in RA.
Authors: Lebogang Mokotedi; Sulé Gunter; Chanel Robinson; Frederic Michel; Ahmed Solomon; Gavin R Norton; Angela J Woodiwiss; Linda Tsang; Patrick H Dessein; Aletta M E Millen Journal: J Cardiovasc Transl Res Date: 2019-05-22 Impact factor: 4.132
Authors: Andrew H Tran; Thomas R Kimball; Philip R Khoury; Lawrence M Dolan; Elaine M Urbina Journal: Arterioscler Thromb Vasc Biol Date: 2020-12-10 Impact factor: 8.311
Authors: Miguel A González-Gay; Patrick H Dessein; Ahmed Solomon; Anne E Stanwix; Santos Castañeda; Javier Llorca; Carlos Gonzalez-Juanatey; Bridget Hodkinson; Benitha Romela; Mahmood M T M Ally; Ajesh B Maharaj; Elsa M Van Duuren; Joyce J Ziki; Mpoti Seboka; Makgotso Mohapi; Barend J Jansen Van Rensburg; Gareth S Tarr; Kavita Makan; Charlene Balton; Aphrodite Gogakis Journal: BMC Rheumatol Date: 2020-06-16