Luis E Simental-Mendía1, Matteo Pirro2, Antonio M Gotto3, Maciej Banach4,5, Stephen L Atkin6, Muhammed Majeed7, Amirhossein Sahebkar8. 1. a Biomedical Research Unit , Mexican Social Security Institute , Durango , Mexico. 2. b Unit of Internal Medicine, Angiology and Arteriosclerosis Diseases, Department of Medicine , University of Perugia , Perugia , Italy. 3. c Weill Cornell Medical College , New York , NY , United States. 4. d Department of Hypertension , WAM University Hospital in Lodz, Medical University of Lodz , Zeromskiego 113, Lodz , Poland. 5. e Polish Mother's Memorial Hospital Research Institute (PMMHRI) , Lodz , Poland. 6. f Weill Cornell Medicine Qatar , Doha , Qatar. 7. g Sabinsa Corporation , East Windsor , NJ , United States. 8. h Biotechnology Research Center , Mashhad University of Medical Sciences , Mashhad , Iran.
Abstract
OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. RESULTS: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: -21.36 mg/dL, 95% CI: -32.18, -10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: -5.82 mg/dL, 95% CI: -15.80, 4.16, p = 0.253) and total cholesterol (WMD: -9.57 mg/dL, 95% CI: -20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. CONCLUSION: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.
OBJECTIVE: The aim of this systematic review and meta-analysis was to determine and clarify the impact of curcuminoids on serum lipid levels. METHODS: Randomized controlled trials (RCTs) investigating the effects of curcuminoids on plasma lipids were searched in PubMed-Medline, Scopus, Web of Science databases (from inception to April 3rd, 2017). A random-effects model and generic inverse variance method were used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. A weighted random-effects meta-regression was performed to evaluate the impact of potential confounders on lipid concentrations. RESULTS: A meta-analysis of 20 RCTs with 1427 participants suggested a significant decrease in plasma concentrations of triglycerides (WMD: -21.36 mg/dL, 95% CI: -32.18, -10.53, p < 0.001), and an elevation in plasma HDL-C levels (WMD: 1.42 mg/dL, 95% CI: 0.03, 2.81, p = 0.046), while plasma levels of LDL-C (WMD: -5.82 mg/dL, 95% CI: -15.80, 4.16, p = 0.253) and total cholesterol (WMD: -9.57 mg/dL, 95% CI: -20.89, 1.75, p = 0.098) were not altered. The effects of curcuminoids on lipids were not found to be dependent on the duration of supplementation. CONCLUSION: This meta-analysis has shown that curcuminoid therapy significantly reduces plasma triglycerides and increases HDL-C levels.