Literature DB >> 29185425

Why do so many clinical trials of therapies for Alzheimer's disease fail?

Roy M Anderson1, Christoforos Hadjichrysanthou2, Stephanie Evans2, Mei Mei Wong2.   

Abstract

Entities:  

Mesh:

Substances:

Year:  2017        PMID: 29185425     DOI: 10.1016/S0140-6736(17)32399-1

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


× No keyword cloud information.
  58 in total

1.  Targeting Age-Related Neurodegenerative Diseases by AAV-Mediated Gene Therapy.

Authors:  Umut Cagin
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 2.  The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease.

Authors:  Bhumsoo Kim; Sarah E Elzinga; Rosemary E Henn; Lisa M McGinley; Eva L Feldman
Journal:  Neurobiol Dis       Date:  2019-07-23       Impact factor: 5.996

Review 3.  Therapeutic Efficacy of Plasmalogens for Alzheimer's Disease, Mild Cognitive Impairment, and Parkinson's Disease in Conjunction with a New Hypothesis for the Etiology of Alzheimer's Disease.

Authors:  Takehiko Fujino; Md Shamim Hossain; Shiro Mawatari
Journal:  Adv Exp Med Biol       Date:  2020       Impact factor: 2.622

Review 4.  Neurotheranostics as personalized medicines.

Authors:  Bhavesh D Kevadiya; Brendan M Ottemann; Midhun Ben Thomas; Insiya Mukadam; Saumya Nigam; JoEllyn McMillan; Santhi Gorantla; Tatiana K Bronich; Benson Edagwa; Howard E Gendelman
Journal:  Adv Drug Deliv Rev       Date:  2018-10-26       Impact factor: 15.470

Review 5.  Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases.

Authors:  Claudio Soto; Sandra Pritzkow
Journal:  Nat Neurosci       Date:  2018-09-24       Impact factor: 24.884

Review 6.  Religious Orders Study and Rush Memory and Aging Project.

Authors:  David A Bennett; Aron S Buchman; Patricia A Boyle; Lisa L Barnes; Robert S Wilson; Julie A Schneider
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

7.  Synthesis, molecular docking, and biological evaluation of novel 2-pyrazoline derivatives as multifunctional agents for the treatment of Alzheimer's disease.

Authors:  Oya Unsal-Tan; Tuba Tüylü Küçükkılınç; Beyza Ayazgök; Ayla Balkan; Keriman Ozadali-Sari
Journal:  Medchemcomm       Date:  2019-05-09       Impact factor: 3.597

8.  Association between sleep structure and amnesic mild cognitive impairment in patients with insomnia disorder: a case-control study.

Authors:  Li Zhang; Tingting Li; Yuhua Lei; Guangwen Cheng; Buyun Liu; YongFei Yu; HongXiang Yin; Lin Song; Qiong La; Benchao Li; Wei Bao; ZhenLi Guo; Shuang Rong
Journal:  J Clin Sleep Med       Date:  2021-01-01       Impact factor: 4.062

Review 9.  Neurological Mechanisms of Animal-Assisted Intervention in Alzheimer's Disease: A Hypothetical Review.

Authors:  Sujin Kim; Yunkwon Nam; Min-Joo Ham; Chisoo Park; Minho Moon; Doo-Han Yoo
Journal:  Front Aging Neurosci       Date:  2021-07-14       Impact factor: 5.750

10.  Synergistic toxicity between tau and amyloid drives neuronal dysfunction and neurodegeneration in transgenic C. elegans.

Authors:  Sarah J Benbow; Timothy J Strovas; Martin Darvas; Aleen Saxton; Brian C Kraemer
Journal:  Hum Mol Genet       Date:  2020-02-01       Impact factor: 6.150

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.