Literature DB >> 2918504

5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines as antihypertensive agents.

W E Meyer1, A S Tomcufcik, P S Chan, M Haug.   

Abstract

A series of 5-(1-piperazinyl)-1H-1,2,4-triazol-3-amines was synthesized and screened for antihypertensive and diuretic activity in spontaneously hypertensive rats (SHR). One compound, 5-[4-[(3-chlorophenyl)methyl]-1-piperazinyl]-1H-1,2,4-triazol-3-am ine (8), was selected to define the mechanism of its antihypertensive activity. Studies in SHR suggest ganglionic blocking activity. Short-lived antihypertensive activity was observed in conscious renal hypertensive dogs.

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Year:  1989        PMID： 2918504     DOI： 10.1021/jm00123a013

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  1 in total

1.  The role of 5-arylalkylamino- and 5-piperazino- moieties on the 7-aminopyrazolo[4,3-d]pyrimidine core in affecting adenosine A1 and A2A receptor affinity and selectivity profiles.

Authors:  Lucia Squarcialupi; Marco Betti; Daniela Catarzi; Flavia Varano; Matteo Falsini; Annalisa Ravani; Silvia Pasquini; Fabrizio Vincenzi; Veronica Salmaso; Mattia Sturlese; Katia Varani; Stefano Moro; Vittoria Colotta
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051
  1 in total

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