Literature DB >> 29184924

5-(Hydroxymethyl)uracil and -cytosine as potential epigenetic marks enhancing or inhibiting transcription with bacterial RNA polymerase.

Martina Janoušková1, Zuzana Vaníková, Fabrizia Nici, Soňa Boháčová, Dragana Vítovská, Hana Šanderová, Michal Hocek, Libor Krásný.   

Abstract

DNA templates containing 5-hydroxymethyluracil or 5-hydroxymethylcytosine were used in an in vitro transcription assay with RNA polymerase from Escherichia coli. A strong enhancement of transcription was observed from DNA containing the Pveg promoter whereas a decrease was observed from DNA containing the rrnB P1 promoter, suggesting that they may act as epigenetic marks.

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Year:  2017        PMID： 29184924     DOI： 10.1039/c7cc08053k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Sequencing 5-Hydroxymethyluracil at Single-Base Resolution.

Authors:  Fumiko Kawasaki; Sergio Martínez Cuesta; Dario Beraldi; Areeb Mahtey; Robyn E Hardisty; Mark Carrington; Shankar Balasubramanian
Journal:  Angew Chem Int Ed Engl       Date:  2018-07-04       Impact factor: 15.336

2.  Modified nucleoside triphosphates in bacterial research for in vitro and live-cell applications.

Authors:  Adeline Espinasse; Hannah K Lembke; Angela A Cao; Erin E Carlson
Journal:  RSC Chem Biol       Date:  2020-09-14

3.  Homologues of epigenetic pyrimidines: 5-alkyl-, 5-hydroxyalkyl and 5-acyluracil and -cytosine nucleotides: synthesis, enzymatic incorporation into DNA and effect on transcription with bacterial RNA polymerase.

Authors:  Filip Gracias; Olatz Ruiz-Larrabeiti; Viola Vaňková Hausnerová; Radek Pohl; Blanka Klepetářová; Veronika Sýkorová; Libor Krásný; Michal Hocek
Journal:  RSC Chem Biol       Date:  2022-06-30

4.  Retracted Article: Divergent synthesis of 5-substituted pyrimidine 2'-deoxynucleosides and their incorporation into oligodeoxynucleotides for the survey of uracil DNA glycosylases.

Authors:  Ai Tran; Song Zheng; Dawanna S White; Alyson M Curry; Yana Cen
Journal:  Chem Sci       Date:  2020-10-07       Impact factor: 9.825
  4 in total

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