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Literature DB >> 29183769

TPL2 kinase action and control of inflammation.

Daqi Xu¹, Marissa L Matsumoto¹, Brent S McKenzie¹, Ali A Zarrin².

Abstract

Tumor progression locus 2 (TPL2, also known as COT or MAP3K8) is a mitogen-activated protein kinase kinase (MAP3K) activated downstream of TNFαR, IL1R, TLR, CD40, IL17R, and some GPCRs. TPL2 regulates the MEK1/2 and ERK1/2 pathways to regulate a cascade of inflammatory responses. In parallel to this, TPL2 also activates p38α and p38δ to drive the production of various inflammatory mediators in neutrophils. We discuss the implications of this finding in the context of various inflammatory diseases.

Entities: Disease Gene

Keywords: Autoimmune disease; COPD; COT; ERK; IBD; Inflammation; MAP3K8; MAPK; Macrophage; Multiple sclerosis; Neutrophil; Phosphorylation; Psoriasis; Rheumatoid arthritis; TLRs; TNFα; TPL2; p38

Mesh：

Substances：

Year: 2017 PMID： 29183769 DOI： 10.1016/j.phrs.2017.11.031

Source DB: PubMed Journal: Pharmacol Res ISSN： 1043-6618 Impact factor: 7.658

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Cited

21 in total

1. TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.

Authors: Yuanguo Wang; Shaohui Wang; Ciaran P Kelly; Hanping Feng; Andrew Greenberg; Xingmin Sun
Journal: Infect Immun Date: 2018-07-23 Impact factor: 3.441

2. Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages.

Authors: Sarah G Groft; Nancy Nagy; W Henry Boom; Clifford V Harding
Journal: Infect Immun Date: 2020-12-15 Impact factor: 3.441

3. Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells.

Authors: Or Kalchiem-Dekel; Xianglan Yao; Amisha V Barochia; Maryann Kaler; Debbie M Figueroa; William B Karkowsky; Elizabeth M Gordon; Meixia Gao; Maria M Fergusson; Xuan Qu; Poching Liu; Yuesheng Li; Fayaz Seifuddin; Mehdi Pirooznia; Stewart J Levine
Journal: Am J Respir Cell Mol Biol Date: 2020-08 Impact factor: 6.914

4. Bioinformatics-Based Analysis of the lncRNA-miRNA-mRNA Network and TF Regulatory Network to Explore the Regulation Mechanism in Spinal Cord Ischemia/Reperfusion Injury.

Authors: Dan Wang; Limei Wang; Jie Han; Zaili Zhang; Bo Fang; Fengshou Chen
Journal: Front Genet Date: 2021-04-27 Impact factor: 4.599

5. TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria.

Authors: Felix Breyer; Anetta Härtlova; Teresa Thurston; Helen R Flynn; Probir Chakravarty; Julia Janzen; Julien Peltier; Tiaan Heunis; Ambrosius P Snijders; Matthias Trost; Steven C Ley
Journal: EMBO J Date: 2021-04-21 Impact factor: 14.012

6. Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.

Authors: Pallavi Chaturvedi; Varghese George; Niraj Shrestha; Meng Wang; Michael J Dee; Xiaoyun Zhu; Bai Liu; Jack Egan; Francesca D'Eramo; Catherine Spanoudis; Victor Gallo; Christian Echeverri; Lijing You; Lin Kong; Byron Fang; Emily K Jeng; Peter R Rhode; Hing C Wong
Journal: Mol Ther Date: 2022-01-17 Impact factor: 11.454

TPL2 kinase action and control of inflammation.

1. TPL2 Is a Key Regulator of Intestinal Inflammation in Clostridium difficile Infection.

2. Toll-Like Receptor 2-Tpl2-Dependent ERK Signaling Drives Inverse Interleukin 12 Regulation in Dendritic Cells and Macrophages.

3. Apolipoprotein E Signals via TLR4 to Induce CXCL5 Secretion by Asthmatic Airway Epithelial Cells.

4. Bioinformatics-Based Analysis of the lncRNA-miRNA-mRNA Network and TF Regulatory Network to Explore the Regulation Mechanism in Spinal Cord Ischemia/Reperfusion Injury.

5. TPL-2 kinase induces phagosome acidification to promote macrophage killing of bacteria.

6. Immunotherapeutic HCW9218 augments anti-tumor activity of chemotherapy via NK cell-mediated reduction of therapy-induced senescent cells.

Review 7. Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review.

Review 8. Tumor progression locus 2 (TPL2) in tumor-promoting Inflammation, Tumorigenesis and Tumor Immunity.

Review 9. Activation of c-Jun N-Terminal Kinase, a Potential Therapeutic Target in Autoimmune Arthritis.

Review 10. Kinase inhibition in autoimmunity and inflammation.