| Literature DB >> 29183709 |
Daniel G Pellicci1, Adam P Uldrich2.
Abstract
Studies of lipid reactive CD1d-restricted T cells have focussed on α-galactosylceramide reactive semi-invariant Type I NKT cells, which influence a broad range of immune responses. Much less is known about other CD1d-restricted T cells with respect to TCR diversity, function, the types of antigens they recognize and how they specifically recognize antigens presented by CD1d. In this review, we reflect on recent literature that highlights unexpected complexity within the pool of CD1d-restricted T cells and emphasize how TCR diversity greatly broadens the scope of antigen recognition.Entities:
Keywords: CD1d; Lipid antigen; Natural Killer T (NKT) cells; T cell receptor (TCR)
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Year: 2017 PMID: 29183709 DOI: 10.1016/j.semcdb.2017.11.031
Source DB: PubMed Journal: Semin Cell Dev Biol ISSN: 1084-9521 Impact factor: 7.727