Gholamreza Badfar1, Masoumeh Shohani2, Ali Soleymani3, Milad Azami4. 1. a Department of Pediatrics , Behbahan Faculty of Medical Sciences , Behbahan , Iran. 2. b Department of Nursing, Faculty of Allied Medical Sciences , Ilam University of Medical Sciences , Ilam , Iran. 3. c Financial Department , Faculty of Medicine, Dezful University of Medical Sciences , Dezful , Iran. 4. d Student Research Committee, Faculty of Medicine , Ilam University of Medical Sciences , Ilam , Iran.
Abstract
OBJECTIVE: Anemia is a major public health and nutritional problem in the world. Studies have reported the relationship between anemia during pregnancy and small for gestational age (SGA). Therefore, the present systematic review and meta-analysis was conducted to determine the relationship between maternal anemia during pregnancy and SGA. METHOD: This meta-analysis was conducted without time limit until April 2017 based on the PRISMA protocol. Several international databases including Cochrane, Scopus, Web of Science (ISI), Pubmed, Embase, and Google Scholar search engine were searched independently by two researchers. The keywords include: anemia, pregnant women, gestational age, and pregnancy. The relative risk (RR) and 95% confidence interval were estimated regarding to the significance of the I2 index based on the random effects model. Data were analyzed using Comprehensive Meta-Analysis Software version 2. RESULTS: Ten studies with a sample size including 620 080 pregnant women entered the meta-analysis process. The overall relationship between maternal anemia during pregnancy and SGA was not significant (RR = 1.11 [95%CI: 0.99-1.24, p = .074]). The relationship between anemia during pregnancy and SGA based on pregnancy trimester showed that maternal anemia was significant in the first trimester, (RR = 1.11 [95%CI: 1-1.22, p = .044]), but this relationship was not significant in the second trimester (RR = 1.11 [95%CI: 0.85-1.18, p = .91]). CONCLUSIONS: Maternal anemia in the first trimester of pregnancy can be considered as a risk factor for negative pregnancy outcomes (SGA).
OBJECTIVE:Anemia is a major public health and nutritional problem in the world. Studies have reported the relationship between anemia during pregnancy and small for gestational age (SGA). Therefore, the present systematic review and meta-analysis was conducted to determine the relationship between maternal anemia during pregnancy and SGA. METHOD: This meta-analysis was conducted without time limit until April 2017 based on the PRISMA protocol. Several international databases including Cochrane, Scopus, Web of Science (ISI), Pubmed, Embase, and Google Scholar search engine were searched independently by two researchers. The keywords include: anemia, pregnant women, gestational age, and pregnancy. The relative risk (RR) and 95% confidence interval were estimated regarding to the significance of the I2 index based on the random effects model. Data were analyzed using Comprehensive Meta-Analysis Software version 2. RESULTS: Ten studies with a sample size including 620 080 pregnant women entered the meta-analysis process. The overall relationship between maternal anemia during pregnancy and SGA was not significant (RR = 1.11 [95%CI: 0.99-1.24, p = .074]). The relationship between anemia during pregnancy and SGA based on pregnancy trimester showed that maternal anemia was significant in the first trimester, (RR = 1.11 [95%CI: 1-1.22, p = .044]), but this relationship was not significant in the second trimester (RR = 1.11 [95%CI: 0.85-1.18, p = .91]). CONCLUSIONS:Maternal anemia in the first trimester of pregnancy can be considered as a risk factor for negative pregnancy outcomes (SGA).
Entities:
Keywords:
Anemia; meta-analysis; pregnancy; small for gestational age
Authors: Ilknur Col Madendag; Mefkure Eraslan Sahin; Yusuf Madendag; Erdem Sahin; Mustafa Bertan Demir; Banu Acmaz; Gokhan Acmaz; Iptisam Ipek Muderris Journal: Biomed Res Int Date: 2019-11-22 Impact factor: 3.411