Eva María Navarrete-Muñoz1,2, Desirée Valera-Gran2, Manuela Garcia-de-la-Hera1,2, Sandra Gonzalez-Palacios2, Isolina Riaño1,3, Mario Murcia1,4, Aitana Lertxundi1,5,6, Mònica Guxens1,7,8,9, Adonina Tardón1,10, Pilar Amiano1,11, Martine Vrijheid1,7,8, Marisa Rebagliato1,4,12, Jesus Vioque13,14. 1. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. 2. Department of Public Health, History of Medicine and Gynecology, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Universidad Miguel Hernández, Ctra. Nacional 332 S/n, Sant Joan D'alacant, 03550, Alicante, Spain. 3. Pediatric Service, Hospital San Agustin, Avilés, Asturias, Spain. 4. Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain. 5. Instituto de Investigación Sanitaria, BIODONOSTIA, San Sebastian, Spain. 6. Departamento de Medicina Preventiva y Salud Pública, Universidad del País Vasco UPV-EHU, Leioa, Spain. 7. ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. 8. Universitat Pompeu Fabra (UPF), Barcelona, Spain. 9. Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre-Sophia Children's Hospital, Rotterdam, The Netherlands. 10. Department of Medicine, Universidad de Oviedo, Oviedo, Asturias, Spain. 11. Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain. 12. Department of Medicine, Universitat Jaume I, Castellón de la Plana, Spain. 13. CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. vioque@umh.es. 14. Department of Public Health, History of Medicine and Gynecology, Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), Universidad Miguel Hernández, Ctra. Nacional 332 S/n, Sant Joan D'alacant, 03550, Alicante, Spain. vioque@umh.es.
Abstract
PURPOSE: We investigated the association between maternal use of folic acid (FA) during pregnancy and child anthropometric measures at birth. METHODS: We included 2302 mother-child pairs from a population-based birth cohort in Spain (INMA Project). FA dosages at first and third trimester of pregnancy were assessed using a specific battery questionnaire and were categorized in non-user, < 1000, 1000-4999, and ≥ 5000 µg/day. Anthropometric measures at birth (weight in grams, length and head circumference in centimetres) were obtained from medical records. Small for gestational age according to weight (SGA-w), length (SGA-l) and head circumference (SGA-hc) were defined using the 10th percentile based on Spanish standardized growth reference charts. Multiple linear and logistic regression analyses were used to explore the association between FA dosages in different stages of pregnancy and child anthropometric measures at birth. RESULTS: In the multiple linear regression analysis, we found a tendency for a negative association between the use of high dosages of FA (≥ 5000 µg/day) in the periconceptional period of pregnancy and weight at birth compared to mothers who were non-users of FA (β = - 73.83; 95% CI - 151.71, 4.06). In the multiple logistic regression, a greater risk of SGA-w was also evident among children whose mothers took FA dosages of 1000-4999 (OR = 2.21; 95% CI 1.17, 4.19) and of ≥ 5000 µg/day (OR = 2.32; 95% CI 1.06, 5.08) compared to mothers non-users of FA in the periconceptional period of pregnancy. CONCLUSION: Our findings suggest that a high dosage of FA (≥ 1000 µg/day) may be associated with an increased risk of SGA-w at birth.
PURPOSE: We investigated the association between maternal use of folic acid (FA) during pregnancy and child anthropometric measures at birth. METHODS: We included 2302 mother-child pairs from a population-based birth cohort in Spain (INMA Project). FA dosages at first and third trimester of pregnancy were assessed using a specific battery questionnaire and were categorized in non-user, < 1000, 1000-4999, and ≥ 5000 µg/day. Anthropometric measures at birth (weight in grams, length and head circumference in centimetres) were obtained from medical records. Small for gestational age according to weight (SGA-w), length (SGA-l) and head circumference (SGA-hc) were defined using the 10th percentile based on Spanish standardized growth reference charts. Multiple linear and logistic regression analyses were used to explore the association between FA dosages in different stages of pregnancy and child anthropometric measures at birth. RESULTS: In the multiple linear regression analysis, we found a tendency for a negative association between the use of high dosages of FA (≥ 5000 µg/day) in the periconceptional period of pregnancy and weight at birth compared to mothers who were non-users of FA (β = - 73.83; 95% CI - 151.71, 4.06). In the multiple logistic regression, a greater risk of SGA-w was also evident among children whose mothers took FA dosages of 1000-4999 (OR = 2.21; 95% CI 1.17, 4.19) and of ≥ 5000 µg/day (OR = 2.32; 95% CI 1.06, 5.08) compared to mothers non-users of FA in the periconceptional period of pregnancy. CONCLUSION: Our findings suggest that a high dosage of FA (≥ 1000 µg/day) may be associated with an increased risk of SGA-w at birth.
Entities:
Keywords:
Cohort study; Folate intake; Folic acid; Pregnancy; Small for gestational age according to weight
Authors: Vineta Fellman; Lena Hellström-Westas; Mikael Norman; Magnus Westgren; Karin Källén; Hugo Lagercrantz; Karel Marsál; Fredrik Serenius; Margareta Wennergren Journal: JAMA Date: 2009-06-03 Impact factor: 56.272
Authors: Gang Cheng; Tingting Sha; Xiao Gao; Qiong He; Xialing Wu; Qianling Tian; Fan Yang; Cai Tang; Xihong Wu; Qunhui Xie; Yan Yan Journal: Int J Environ Res Public Health Date: 2019-11-15 Impact factor: 3.390
Authors: Jing Lin; Cheng Wang; Sisi Li; Jie Zhang; Lei Jin; Mingkun Tong; Wenying Meng; Aiguo Ren; Lei Chen; Lei Jin Journal: Front Pediatr Date: 2022-04-28 Impact factor: 3.418
Authors: Laura María Compañ-Gabucio; Laura Torres-Collado; Manuela Garcia-de la Hera; Ana Fernández-Somoano; Adonina Tardón; Jordi Julvez; Jordi Sunyer; Marisa Rebagliato; Mario Murcia; Jesús Ibarluzea; Loreto Santa-Marina; Jesús Vioque Journal: Int J Environ Res Public Health Date: 2022-09-25 Impact factor: 4.614
Authors: Sofía Aguilar-Lacasaña; Inmaculada López-Flores; Beatriz González-Alzaga; María José Giménez-Asensio; F David Carmona; Antonio F Hernández; María Felicidad López Gallego; Desirée Romero-Molina; Marina Lacasaña Journal: Nutrients Date: 2021-03-03 Impact factor: 5.717