Literature DB >> 29181568

Amexanthomycins A-J, pentangular polyphenols produced by Amycolatopsis mediterranei S699∆rifA.

Xiaomei Li1, Xingkang Wu1, Jing Zhu2, Yuemao Shen3,4.   

Abstract

Ten new pentangular polyphenols, namely amexanthomycins A-J (1-10) were isolated from the strain Amycolatopsis mediterranei S699∆rifA constructed by deleting the polyketide synthase genes responsible for the biosynthesis of rifamycins. Their structures were elucidated on the basis of 1D and 2D NMR spectroscopic data and high-resolution ESIMS. Amexanthomycins A-C (1-3) showed inhibitory activity against human DNA topoisomerases.

Entities:  

Keywords:  Amycolatopsis mediterranei S699; Pentangular polyphenols; Topoisomerase IIα inhibitor; min-PKS

Mesh：

Substances：

Year:  2017        PMID： 29181568     DOI： 10.1007/s00253-017-8648-z

Source DB:  PubMed          Journal:  Appl Microbiol Biotechnol        ISSN： 0175-7598            Impact factor:   4.813


  4 in total

Review 1.  Concepts and Methods to Access Novel Antibiotics from Actinomycetes.

Authors:  Joachim J Hug; Chantal D Bader; Maja Remškar; Katarina Cirnski; Rolf Müller
Journal:  Antibiotics (Basel)       Date:  2018-05-22

2.  Integrating vectors for genetic studies in the rare Actinomycete Amycolatopsis marina.

Authors:  Hong Gao; Buvani Murugesan; Janina Hoßbach; Stephanie K Evans; W Marshall Stark; Margaret C M Smith
Journal:  BMC Biotechnol       Date:  2019-06-04       Impact factor: 2.563

3.  Enzymatic spiroketal formation via oxidative rearrangement of pentangular polyketides.

Authors:  Britta Frensch; Thorsten Lechtenberg; Michel Kather; Zeynep Yunt; Martin Betschart; Bernd Kammerer; Steffen Lüdeke; Michael Müller; Jörn Piel; Robin Teufel
Journal:  Nat Commun       Date:  2021-03-04       Impact factor: 14.919

Review 4.  Secondary Metabolites of the Genus Amycolatopsis: Structures, Bioactivities and Biosynthesis.

Authors:  Zhiqiang Song; Tangchang Xu; Junfei Wang; Yage Hou; Chuansheng Liu; Sisi Liu; Shaohua Wu
Journal:  Molecules       Date:  2021-03-26       Impact factor: 4.411
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.