| Literature DB >> 29181386 |
Juste Baranauskaite1, Asta Kubiliene2, Mindaugas Marksa2, Vilma Petrikaite3, Konradas Vitkevičius2, Algirdas Baranauskas1, Jurga Bernatoniene1.
Abstract
The aim of this study was to evaluate concentration-dependent antioxidant and anticancer activities of CA and RA in ethanol extracts of three different Oregano species (Origanum onites L., Origanum vulgare L., and Origanum vulgare ssp. hirtum). The study revealed the highest RA antioxidant activity in O. vulgare ssp. hirtum (9550 ± 95 mmol/g) and the lowest in O. vulgare L. (2605 ± 52 mmol/g) (p < 0.05). The highest CA amount was present in O. onites L., which was 1.8 and 4.7 times higher (p < 0.05) than in O. vulgare ssp. hirtum and O. vulgare L., respectively. The anticancer activity was evaluated on human glioblastoma (U87) and triple-negative breast cancer (MDA-MB231) cell lines in vitro. RA anticancer activity was negligible. CA and the extracts were about 1.5-2 times more active against MDA-MB231 cell line (p < 0.05) compared to U87 cell line. The anticancer activities of three tested extracts were similar against U87 cell line (p > 0.05) but they had different activities against MDA-MB231 cell line.Entities:
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Year: 2017 PMID： 29181386 PMCID： PMC5664182 DOI： 10.1155/2017/1681392
Source DB: PubMed Journal: Biomed Res Int Impact factor: 3.411