| Literature DB >> 29181106 |
Yang Jiang1, Hui Li2, Yi Wang3, Tian Tian3, Yan He1, Yinji Jin1, Changsong Han1, Xiaoming Jin1, Fengmin Zhang4, Eiichi Morii3.
Abstract
The present study aimed to examine whether the enzyme activity of aldehyde dehydrogenase (ALDH) was regulated by Nodal and histamine in the human alveolar adenocarcinoma A549 cell line. The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma. The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). ALDH activity was also downregulated by recombinant human Nodal and antagonists of H1R and H2R in the A549 cell line. In addition, expression of Nodal and ALDH1 were inversely correlated in lung mixed adenocarcinoma. ALDH enzyme activity was regulated by Nodal and histamine in lung adenocarcinoma.Entities:
Keywords: A549; aldehyde dehydrogenase; histamine; lung mixed adenocarcinoma; nodal
Year: 2017 PMID： 29181106 PMCID： PMC5696712 DOI： 10.3892/ol.2017.7057
Source DB: PubMed Journal: Oncol Lett ISSN： 1792-1074 Impact factor: 2.967