| Literature DB >> 29180259 |
David R Skvarc1, Michael Berk2, Linda K Byrne3, Olivia M Dean4, Seetal Dodd5, Matthew Lewis6, Andrew Marriott7, Eileen M Moore8, Gerwyn Morris9, Richard S Page10, Laura Gray11.
Abstract
Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with significant clinical, social and financial impacts for patients and their communities. The underlying pathophysiology is becoming increasingly understood, with the role of neuroinflammation and oxidative stress secondary to surgery and anaesthesia strongly implicated. This review aims to describe the putative mechanisms by which surgery-induced inflammation produces cognitive sequelae, with a focus on identifying potential novel therapies based upon their ability to modify these pathways. CrownEntities:
Keywords: Biomarkers; Cognition; Neuroinflammation; Oxidative stress; Post-operative cognitive dysfunction
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Year: 2017 PMID： 29180259 DOI： 10.1016/j.neubiorev.2017.11.011
Source DB: PubMed Journal: Neurosci Biobehav Rev ISSN： 0149-7634 Impact factor: 8.989