Morten Wibroe1, Per Rochat2, Marianne Juhler2. 1. Neurosurgical Department, University Hospital Rigshospitalet, Copenhagen, Denmark; Paediatric Department, University Hospital Rigshospitalet, Copenhagen, Denmark. Electronic address: morten.wibroe@regionh.dk. 2. Neurosurgical Department, University Hospital Rigshospitalet, Copenhagen, Denmark.
Abstract
BACKGROUND: Cerebellar mutism syndrome (CMS) is rarely described in adults; however, data on self-assessed linguistic complications after posterior fossa surgery do not exist. METHODS: Through a prospective single-center study, data on 59 tumor operations in the posterior fossa were collected preoperatively as well as 1 week and 1 month postoperatively. Data on self-assessed problems in 5 CMS-related domains, CMS scores, and neurology as well as surgical procedure and complications were obtained. RESULTS: Data on CMS-related complications were obtained on 56 of the 59 operations. None was found to have CMS according to the CMS score. Within each of the 5 domains, at least 9 operations (16%) were followed by development or worsening of self-assessed CMS-related complications. Self-assessed complications were found to be most frequent after primary tumor surgeries, although they were significant only for speech and motor complications (P value = 0.01 and 0.02). Speech and language complications occurred more frequently in midline tumors compared with lateral tumors (40% vs. 7%; P = 0.004). Surgical complications were similar to other studies. CONCLUSIONS: We propose that speech and language problems in adults undergoing surgery in the posterior fossa occur more frequently than previously assumed. Some of the self-assessed complications might reflect components of the cerebellar cognitive affective syndrome. Our findings are consistent with the fact that midline location of the tumor is one of the few known risk factors for CMS in children. Thus, the cerebellar midline seems to be a vulnerable region for speech and language complications also in adults.
BACKGROUND:Cerebellar mutism syndrome (CMS) is rarely described in adults; however, data on self-assessed linguistic complications after posterior fossa surgery do not exist. METHODS: Through a prospective single-center study, data on 59 tumor operations in the posterior fossa were collected preoperatively as well as 1 week and 1 month postoperatively. Data on self-assessed problems in 5 CMS-related domains, CMS scores, and neurology as well as surgical procedure and complications were obtained. RESULTS: Data on CMS-related complications were obtained on 56 of the 59 operations. None was found to have CMS according to the CMS score. Within each of the 5 domains, at least 9 operations (16%) were followed by development or worsening of self-assessed CMS-related complications. Self-assessed complications were found to be most frequent after primary tumor surgeries, although they were significant only for speech and motor complications (P value = 0.01 and 0.02). Speech and language complications occurred more frequently in midline tumors compared with lateral tumors (40% vs. 7%; P = 0.004). Surgical complications were similar to other studies. CONCLUSIONS: We propose that speech and language problems in adults undergoing surgery in the posterior fossa occur more frequently than previously assumed. Some of the self-assessed complications might reflect components of the cerebellar cognitive affective syndrome. Our findings are consistent with the fact that midline location of the tumor is one of the few known risk factors for CMS in children. Thus, the cerebellar midline seems to be a vulnerable region for speech and language complications also in adults.
Authors: Abd Elrhman Enayet; Mohamed Nabil; Mohamed Reda Rady; Yasser Yousef; Eman Badawy; Mohamed A El Beltagy Journal: Childs Nerv Syst Date: 2021-02-18 Impact factor: 1.475
Authors: Camilla de Laurentis; Paola M F Cristaldi; Paola Rebora; Maria Grazia Valsecchi; Veronica Biassoni; Elisabetta Schiavello; Giorgio G Carrabba; Andrea Trezza; Francesco DiMeco; Paolo Ferroli; Giuseppe Cinalli; Marco Locatelli; Marco Cenzato; Giuseppe Talamonti; Marco M Fontanella; Giannatonio Spena; Roberto Stefini; Claudio Bernucci; Silvio Bellocchi; Davide Locatelli; Maura Massimino; Carlo Giussani Journal: J Neurooncol Date: 2022-06-29 Impact factor: 4.506