Gülnihal Emrem Doğan1, Ayşe Toraman1, Saime Özbek Şebin2, Çetin Doğan3, Adem Güngör3, Hülya Aksoy4, Hilal Asutay5. 1. Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. 2. Department of Physiology, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 3. Department of Internal Medicine, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 4. Department of Medical Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey. 5. Department of Prosthodontics, Faculty of Dentistry, Afyon University, Afyon, Turkey.
Abstract
PURPOSE: To evaluate the association between cytokines IL-6 and IL-10 in saliva, obesity and periodontal disease. METHODS: The study was carried out in 40 subjects: 20 obese subjects with gingivitis and 20 non-obese subjects with gingivitis (controls). Periodontal parameters such as gingival index (GI) and plaque index (PI) of subjects were recorded. Saliva samples were used for measuring IL-6 and IL-10 levels by ELISA method. RESULTS: Saliva IL-6 levels were significantly higher in obese subjects than those of non-obese subjects (P= 0.002). When total groups were evaluated, negative significant correlation between GI and salivary IL-10 levels (r= -0.452, P= 0.003) and positive correlations between salivary IL-6 level and body mass index (BMI) (r= 0.369, P= 0.019) were found. There was a negative correlation between the GI and salivary IL-10 levels in obese subjects (r= -0.548, P= 0.012). Also there was a positive correlation between the salivary level of IL-6 and IL-10 in obese subjects (r= 0.594, P= 0.006). CLINICAL SIGNIFICANCE: Obesity and adipose tissues can affect periodontal health by altering the levels of IL-6 and IL-10. IL-6 in saliva clearly increased in subjects with obesity compared to subjects without obesity. Also negative correlations between saliva IL-10 levels and GI were found in the total group and obese subjects.
PURPOSE: To evaluate the association between cytokines IL-6 and IL-10 in saliva, obesity and periodontal disease. METHODS: The study was carried out in 40 subjects: 20 obese subjects with gingivitis and 20 non-obese subjects with gingivitis (controls). Periodontal parameters such as gingival index (GI) and plaque index (PI) of subjects were recorded. Saliva samples were used for measuring IL-6 and IL-10 levels by ELISA method. RESULTS: Saliva IL-6 levels were significantly higher in obese subjects than those of non-obese subjects (P= 0.002). When total groups were evaluated, negative significant correlation between GI and salivary IL-10 levels (r= -0.452, P= 0.003) and positive correlations between salivary IL-6 level and body mass index (BMI) (r= 0.369, P= 0.019) were found. There was a negative correlation between the GI and salivary IL-10 levels in obese subjects (r= -0.548, P= 0.012). Also there was a positive correlation between the salivary level of IL-6 and IL-10 in obese subjects (r= 0.594, P= 0.006). CLINICAL SIGNIFICANCE: Obesity and adipose tissues can affect periodontal health by altering the levels of IL-6 and IL-10. IL-6 in saliva clearly increased in subjects with obesity compared to subjects without obesity. Also negative correlations between saliva IL-10 levels and GI were found in the total group and obese subjects.
Authors: Saúl Ramírez-De Los Santos; Edgar Iván López-Pulido; Isabel Del Carmen Medrano-González; Julieta Saraí Becerra-Ruiz; Carmen Celina Alonso-Sanchez; Sonia Isela Vázquez-Jiménez; Celia Guerrero-Velázquez; Juan Manuel Guzmán-Flores Journal: Odontology Date: 2020-04-13 Impact factor: 2.634
Authors: Karen L Saban; Herbert L Mathews; Fred B Bryant; Dina Tell; Cara Joyce; Holli A DeVon; Linda Witek Janusek Journal: Brain Behav Immun Date: 2018-07-17 Impact factor: 7.217