Wei Chen1, Anne B Newman2, Linda F Fried3, Dena E Rifkin4, Michael G Shlipak5, Mark J Sarnak6, Ronit Katz7, Magdalena Madero8, Kalani L Raphael9, David A Bushinsky1, Joachim H Ix4,10. 1. Department of Medicine, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA. 2. Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA. 3. Renal Section, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, Pennsylvania. 4. Department of Medicine, University of California San Diego, San Diego, CA, USA. 5. General Internal Medicine Section, VA Medical Center, University of California, San Francisco, CA, USA. 6. Department of Nephrology, Tufts Medical Center, Boston, MA, USA. 7. Department of Biostatistics, University of Washington, Seattle, WA, USA. 8. Instituto Nacional de Cardiología Ignacio Chávez. 9. Internal Medicine, University of Utah, Salt Lake City, UT, USA. 10. Veterans Affairs San Diego Healthcare System, San Diego, CA, USA.
Abstract
Background: Animal studies suggest that acidosis protects against arterial calcification, which contributes to arterial stiffness. The goal of this study was to investigate the associations of serum bicarbonate and pH with arterial stiffness in community-living older adults. Methods: We performed cross-sectional analyses among 1698 well-functioning participants 70-79 years of age. Bicarbonate and pH were measured by arterialized venous blood gas at the point of care. Bicarbonate was categorized into low (<23 mEq/L), normal (23-27.9) and high (≥28). Arterialized venous pH (AVpH) was categorized into tertiles: ≤7.40, >7.40-7.42 and >7.42. Arterial stiffness was evaluated by pulse wave velocity (PWV) and high ankle-brachial index (ABI; >1.3/incompressible). We used linear and logistic regression to evaluate the association of bicarbonate and AVpH with PWV and high ABI, respectively. Results: The mean age was 76 years and 15% had an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. The mean bicarbonate was 25.2 ± 2.1 mEq/L and the mean AVpH was 7.41 ± 0.03. Compared with participants in the normal bicarbonate category, those in the low bicarbonate group had 8.8% higher PWV (P = 0.006) and 1.87 greater odds of high ABI (P = 0.04). However, the associations were not significant after adjusting for eGFR (P = 0.24 and 0.43, respectively). There was no difference in PWV or high ABI across AVpH tertiles. Results were similar in those with and without chronic kidney disease and after excluding participants on diuretics. Conclusions: We did not observe an independent association of bicarbonate or AVpH with arterial stiffness measured by high PWV or ABI in community-living older individuals. Future studies evaluating patients with a greater severity of chronic kidney disease and with more extreme alterations in acid-base status are warranted.
Background: Animal studies suggest that acidosis protects against arterial calcification, which contributes to arterial stiffness. The goal of this study was to investigate the associations of serum bicarbonate and pH with arterial stiffness in community-living older adults. Methods: We performed cross-sectional analyses among 1698 well-functioning participants 70-79 years of age. Bicarbonate and pH were measured by arterialized venous blood gas at the point of care. Bicarbonate was categorized into low (<23 mEq/L), normal (23-27.9) and high (≥28). Arterialized venous pH (AVpH) was categorized into tertiles: ≤7.40, >7.40-7.42 and >7.42. Arterial stiffness was evaluated by pulse wave velocity (PWV) and high ankle-brachial index (ABI; >1.3/incompressible). We used linear and logistic regression to evaluate the association of bicarbonate and AVpH with PWV and high ABI, respectively. Results: The mean age was 76 years and 15% had an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2. The mean bicarbonate was 25.2 ± 2.1 mEq/L and the mean AVpH was 7.41 ± 0.03. Compared with participants in the normal bicarbonate category, those in the low bicarbonate group had 8.8% higher PWV (P = 0.006) and 1.87 greater odds of high ABI (P = 0.04). However, the associations were not significant after adjusting for eGFR (P = 0.24 and 0.43, respectively). There was no difference in PWV or high ABI across AVpH tertiles. Results were similar in those with and without chronic kidney disease and after excluding participants on diuretics. Conclusions: We did not observe an independent association of bicarbonate or AVpH with arterial stiffness measured by high PWV or ABI in community-living older individuals. Future studies evaluating patients with a greater severity of chronic kidney disease and with more extreme alterations in acid-base status are warranted.
Authors: Kirsten Bibbins-Domingo; Glenn M Chertow; Linda F Fried; Michelle C Odden; Anne B Newman; Stephen B Kritchevsky; Tamara B Harris; Suzanne Satterfield; Steven R Cummings; Michael G Shlipak Journal: Arch Intern Med Date: 2006-07-10
Authors: Lesley A Inker; Christopher H Schmid; Hocine Tighiouart; John H Eckfeldt; Harold I Feldman; Tom Greene; John W Kusek; Jane Manzi; Frederick Van Lente; Yaping Lucy Zhang; Josef Coresh; Andrew S Levey Journal: N Engl J Med Date: 2012-07-05 Impact factor: 91.245
Authors: Terence M Doherty; Kamlesh Asotra; Lorraine A Fitzpatrick; Jian-Hua Qiao; Douglas J Wilkin; Robert C Detrano; Colin R Dunstan; Prediman K Shah; Tripathi B Rajavashisth Journal: Proc Natl Acad Sci U S A Date: 2003-09-19 Impact factor: 11.205