Literature DB >> 2917656

Unique substrate specificity and regulatory properties of PKC-epsilon: a rationale for diversity.

D Schaap1, P J Parker, A Bristol, R Kriz, J Knopf.   

Abstract

PKC-epsilon was isolated from a murine brain cDNA library. The clone, lambda 61PKC-epsilon, encoded a polypeptide of 737 amino acids that is homologous to other PKCs. Northern analysis showed that the 7 kb mRNA for this cDNA is widely expressed. The protein when expressed in COS-1 cells displayed phorbol ester-binding activity. However in order to detect the kinase activity of PKC-epsilon, it was necessary to employ a synthetic peptide substrate based upon the pseudosubstrate site. Subsequent analysis demonstrated that PKC-epsilon, while showing certain properties characteristic of the PKC family, has a quite distinct substrate specificity and is independent of Ca2+.

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Year:  1989        PMID： 2917656     DOI： 10.1016/0014-5793(89)80160-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  41 in total

Review 1.  Activation and regulation of protein kinase C enzymes.

Authors:  G L Nelsestuen; M D Bazzi
Journal:  J Bioenerg Biomembr       Date:  1991-02       Impact factor: 2.945

2.  The regulatory domain of protein kinase C-epsilon restricts the catalytic-domain-specificity.

Authors:  C Pears; D Schaap; P J Parker
Journal:  Biochem J       Date:  1991-05-15       Impact factor: 3.857

3.  Role of protein kinase C in the inhibitory action of trophoblast interferons on expression of the oxytocin receptor in sheep endometrium.

Authors:  D R Abayasekara; E L Sheldrick; H C Flick-Smith; A P Flint
Journal:  Endocrine       Date:  1995-02       Impact factor: 3.633

Review 4.  Atypical protein kinase Cι as a human oncogene and therapeutic target.

Authors:  Peter J Parker; Verline Justilien; Philippe Riou; Mark Linch; Alan P Fields
Journal:  Biochem Pharmacol       Date:  2013-11-11       Impact factor: 5.858

5.  Isolation of cloned mouse protein kinase C beta-II cDNA and its sequence.

Authors:  Y M Tang; C L Ashendel
Journal:  Nucleic Acids Res       Date:  1990-09-11       Impact factor: 16.971

6.  Protein kinase C group B members PKC-delta, -epsilon, -zeta and PKC-L(eta). Comparison of properties of recombinant proteins in vitro and in vivo.

Authors:  M Liyanage; D Frith; E Livneh; S Stabel
Journal:  Biochem J       Date:  1992-05-01       Impact factor: 3.857

7.  Diacylglycerol kinase is phosphorylated in vivo upon stimulation of the epidermal growth factor receptor and serine/threonine kinases, including protein kinase C-epsilon.

Authors:  D Schaap; J van der Wal; W J van Blitterswijk; R L van der Bend; H L Ploegh
Journal:  Biochem J       Date:  1993-02-01       Impact factor: 3.857

8.  Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function.

Authors:  C Lehel; Z Olah; G Jakab; W B Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

9.  Expression of mammalian protein kinase C in Schizosaccharomyces pombe: isotype-specific induction of growth arrest, vesicle formation, and endocytosis.

Authors:  N T Goode; M A Hajibagheri; G Warren; P J Parker
Journal:  Mol Biol Cell       Date:  1994-08       Impact factor: 4.138

10.  Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

Authors:  K Ogita; S Miyamoto; K Yamaguchi; H Koide; N Fujisawa; U Kikkawa; S Sahara; Y Fukami; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205
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