Samuel A Adegoke1,2, Josefina A P Braga3, Adekunle D Adekile4, Maria S Figueiredo1. 1. Haematology and Blood Transfusion Division. 2. Department of Pediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, Nigeria. 3. Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de São Paulo, Brazil. 4. Department of Paediatrics, Faculty of Medicine, Kuwait University, Kuwait.
Abstract
OBJECTIVE: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). DESIGN: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. RESULTS: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.1±1.2 vs. 19.1±9.8 ng/mL, P=0.007). CONCLUSIONS: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
OBJECTIVE: To evaluate the impact of hydroxyurea (HU) on nutritional status and serum 25-hydroxyvitamin D (25-OHD) of children with sickle cell disease (SCD). DESIGN: Anthropometry and serum 25-OHD were determined in 98 children with SCD, comprising of 68 in HU-group and 30 in HU-naive group. RESULTS: Underweight was more common among HU-naive group (33.3% vs. 10.3%, P=0.009), while 79.4% of HU-group against 56.7% HU-naive had normal body mass index percentile for age and sex, P=0.028. None of the HU-group compared with 13.3% of the HU-naive had severe vitamin D deficiency, P=0.002. The mean 25-OHD of the HU-group was also higher (24.1±1.2 vs. 19.1±9.8 ng/mL, P=0.007). CONCLUSIONS: HU possibly ameliorate growth retardation and vitamin D deficiency in children with SCD.
Authors: Oyebimpe O Adesina; James G Gurney; Guolian Kang; Martha Villavicencio; Jason R Hodges; Wassim Chemaitilly; Sue C Kaste; Babette S Zemel; Jane S Hankins Journal: Blood Adv Date: 2019-05-14
Authors: Anna M Hood; Charles T Quinn; Christopher D King; Lisa M Shook; James L Peugh; Lori E Crosby Journal: Complement Ther Med Date: 2020-02-15 Impact factor: 2.446