| Literature DB >> 29175156 |
Li-Xia Du1, Yan-Qing Wang1, Guo-Qiang Hua2, Wen-Li Mi3.
Abstract
Interleukin (IL)-33 is a member of the interleukin-1 cytokine family that is produced by many different types of tissues including the central nervous system (CNS). IL-33 mediates its effects via its heterodimeric receptor complex, comprised of ST2 and the IL-1 receptor accessory protein (IL-1RAcp). As a pleiotropic nuclear cytokine, IL-33 is a crucial factor in the development of cardiovascular diseases, allergic diseases, infectious diseases, and autoimmune diseases. Recently, accumulated evidence shows that the IL-33/ST2 axis plays a crucial and diverse role in the pathogenesis of CNS diseases, including neurodegenerative diseases, cerebrovascular diseases, infectious diseases, traumatic CNS injury, chronic pain, etc. In this review, we discuss the recent findings in the cellular signaling of IL-33 and advancement of the role of IL-33 in several CNS diseases, as well as its therapeutic potential for the treatment of those diseases.Entities:
Keywords: ST2; central nervous system diseases; interleukin-33; signaling
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Year: 2017 PMID： 29175156 DOI： 10.1016/j.neuroscience.2017.11.028
Source DB: PubMed Journal: Neuroscience ISSN： 0306-4522 Impact factor: 3.590