Literature DB >> 29175121

Elevated unmethylated and methylated insulin DNA are unique markers of A+β+ ketosis prone diabetes.

Surya N Mulukutla1, Sarah A Tersey2, Christiane S Hampe3, Raghavendra G Mirmira4, Ashok Balasubramanyam5.   

Abstract

A+β+ ketosis prone diabetes (KPD) is associated with slowly progressive autoimmune beta cell destruction. Plasma unmethylated and methylated insulin DNA (biomarkers of ongoing beta cell damage and systemic inflammation, respectively) were elevated in A+β+ KPD compared to all other KPD subgroups.
Copyright © 2017. Published by Elsevier Inc.

Entities:  

Keywords:  Beta cell death; Diabetic Ketoacidosis; Insulin DNA; Islet dysfunction; Ketosis prone diabetes

Mesh：

Substances：

Year:  2017        PMID： 29175121      PMCID： PMC6170161          DOI： 10.1016/j.jdiacomp.2017.10.013

Source DB:  PubMed          Journal:  J Diabetes Complications        ISSN： 1056-8727            Impact factor:   2.852


  8 in total

1.  Detection of β cell death in diabetes using differentially methylated circulating DNA.

Authors:  Eitan M Akirav; Jasmin Lebastchi; Eva M Galvan; Octavian Henegariu; Michael Akirav; Vitaly Ablamunits; Paul M Lizardi; Kevan C Herold
Journal:  Proc Natl Acad Sci U S A       Date:  2011-11-09       Impact factor: 11.205

2.  Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death.

Authors:  Sarah A Tersey; Jennifer B Nelson; Marisa M Fisher; Raghavendra G Mirmira
Journal:  J Vis Exp       Date:  2016-12-21       Impact factor: 1.355

3.  Factors associated with early relapse to insulin dependence in unprovoked A-β+ ketosis-prone diabetes.

Authors:  Ruchi Gaba; Dhiraj Gambhire; Natalie Uy; Erica V Gonzalez; Dinakar Iyer; Christiane S Hampe; Nalini Ram; Ashok Balasubramanyam
Journal:  J Diabetes Complications       Date:  2015-04-30       Impact factor: 2.852

4.  Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA.

Authors:  Marisa M Fisher; Cristina N Perez Chumbiauca; Kieren J Mather; Raghavendra G Mirmira; Sarah A Tersey
Journal:  Endocrinology       Date:  2013-07-03       Impact factor: 4.736

5.  Accuracy and predictive value of classification schemes for ketosis-prone diabetes.

Authors:  Ashok Balasubramanyam; Gilberto Garza; Lucille Rodriguez; Christiane S Hampe; Lakshmi Gaur; Ake Lernmark; Mario R Maldonado
Journal:  Diabetes Care       Date:  2006-12       Impact factor: 19.112

Review 6.  Syndromes of ketosis-prone diabetes mellitus.

Authors:  Ashok Balasubramanyam; Ramaswami Nalini; Christiane S Hampe; Mario Maldonado
Journal:  Endocr Rev       Date:  2008-02-21       Impact factor: 19.871

7.  Ketosis-prone diabetes: dissection of a heterogeneous syndrome using an immunogenetic and beta-cell functional classification, prospective analysis, and clinical outcomes.

Authors:  Mario Maldonado; Christiane S Hampe; Lakshmi K Gaur; Susana D'Amico; Dinakar Iyer; Lisa P Hammerle; Douglas Bolgiano; Lucille Rodriguez; Arun Rajan; Ake Lernmark; Ashok Balasubramanyam
Journal:  J Clin Endocrinol Metab       Date:  2003-11       Impact factor: 5.958

8.  Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes.

Authors:  Marisa M Fisher; Renecia A Watkins; Janice Blum; Carmella Evans-Molina; Naga Chalasani; Linda A DiMeglio; Kieren J Mather; Sarah A Tersey; Raghavendra G Mirmira
Journal:  Diabetes       Date:  2015-07-27       Impact factor: 9.461
  8 in total
  3 in total

Review 1.  Biomarkers of islet beta cell stress and death in type 1 diabetes.

Authors:  Emily K Sims; Carmella Evans-Molina; Sarah A Tersey; Decio L Eizirik; Raghavendra G Mirmira
Journal:  Diabetologia       Date:  2018-08-15       Impact factor: 10.122

2.  Circulating Unmethylated Insulin DNA As a Biomarker of Human Beta Cell Death: A Multi-laboratory Assay Comparison.

Authors:  Cate Speake; Alyssa Ylescupidez; Daniel Neiman; Ruth Shemer; Benjamin Glaser; Sarah A Tersey; Sahar Usmani-Brown; Pamela Clark; Joshua J Wilhelm; Melena D Bellin; Kevan C Herold; Raghavendra G Mirmira; Yuval Dor; Carmella Evans-Molina
Journal:  J Clin Endocrinol Metab       Date:  2020-03-01       Impact factor: 6.134

Review 3.  Cell-Free DNA Fragments as Biomarkers of Islet β-Cell Death in Obesity and Type 2 Diabetes.

Authors:  Marilyn Arosemena; Farah A Meah; Kieren J Mather; Sarah A Tersey; Raghavendra G Mirmira
Journal:  Int J Mol Sci       Date:  2021-02-21       Impact factor: 5.923
  3 in total

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