Kentaro Sugano1, Shinzo Hiroi2, Yoshio Yamaoka3. 1. Department of Medicine, Jichi Medical University, Shimotsuke, Tochigi, Japan. 2. Japan Medical Affairs, Takeda Pharmaceutical Company Limited, Chuo-ku, Tokyo, Japan. 3. Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Oita, Japan.