| Literature DB >> 29174510 |
Yuxing Lin1, Yuqi Gao1, Zhao Ma1, Tianyu Jiang1, Xin Zhou1, Zhenzhen Li1, Xiaojun Qin1, Yun Huang2, Lupei Du1, Minyong Li3.
Abstract
To detect γ-Glutamyl Transpeptidase (GGT) activity in vitro and in vivo, a bioluminescence probe with high sensitivity and specificity was well designed and synthesized. This probe can be recognized by GGT and release strong bioluminescence with its further reaction with luciferase. The performance of this probe was demonstrated in vitro and in cells. Finally, we applied the probe for detection of GGT activity in xenograft model.Entities:
Keywords: Bioluminescence probe; In vivo imaging; γ-Glutamyl transpeptidase
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Year: 2017 PMID： 29174510 DOI： 10.1016/j.bmc.2017.11.025
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641