Literature DB >> 29173944

Isosteric ribavirin analogues: Synthesis and antiviral activities.

Nikolay I Zhurilo1, Mikhail V Chudinov2, Andrey V Matveev1, Olga S Smirnova3, Irina D Konstantinova3, Anatoly I Miroshnikov3, Alexander N Prutkov4, Lyubov E Grebenkina4, Natalya V Pulkova4, Vitaly I Shvets1.   

Abstract

The novel isosteric ribavirin analogues were synthesized by two different ways. Some of them showed significant antiviral action against hepatitis C virus (HCV), herpes simplex (HCV-1) and influenza A virus comparable to that of ribavirin itself. The data obtained confirm the proposed theory of the ribavirin possible antiviral activity mechanism related with bioisosterism.
Copyright © 2017 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Antivirals; Isosterism; Nucleoside analogues; Ribavirin

Mesh：

Substances：

Year:  2017        PMID： 29173944     DOI： 10.1016/j.bmcl.2017.11.029

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


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