Yuki Matsumura1, Hiroyuki Suzuki2, Tetsuya Ohira3, Satoshi Shiono4, Jiro Abe5, Motoyasu Sagawa6, Akira Sakurada7, Masato Katahira4, Yuichiro Machida8, Satomi Takahashi5, Yoshinori Okada7. 1. Department of Chest Surgery, Fukushima Medical University, School of Medicine, Fukushima, Japan. Electronic address: yukimatsumura1980@gmail.com. 2. Department of Chest Surgery, Fukushima Medical University, School of Medicine, Fukushima, Japan. 3. Department of Epidemiology, Fukushima Medical University, School of Medicine, Fukushima, Japan. 4. Departments of Thoracic Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan. 5. Department of Thoracic Surgery, Miyagi Cancer Center, Natori, Miyagi, Japan. 6. Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan; Department of Endoscopy, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. 7. Department of Thoracic Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan. 8. Department of Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Abstract
OBJECTIVE: It is unclear whether epidermal growth factor receptor (EGFR) mutation status is a risk factor for postoperative recurrence of surgically resected lung adenocarcinoma (ADC). Therefore, we conducted a multi-institutional study employing matched-pair analysis to compare recurrence-free survival (RFS) and overall survival (OS) of patients with lung ADC according to EGFR mutation status. METHODS: We collected the records of 909 patients who underwent surgical resection for lung ADC between 2005 and 2012 at five participating institutions and were also examined their EGFR mutation status. For each patient with an EGFR mutation, we selected one with the wild-type EGFR sequence and matched them according to institution, age, gender, smoking history, pathological stage (pStage), and adjuvant treatment. We compared RFS and OS of the matched cohort. RESULTS: The patients were allocated into groups (n=181 each) with mutated or wild-type EGFR sequences. Both cohorts had identical characteristics as follows: institution, median age (68 years), men (85, 47%), ever smokers (77, 43%), and pStage (IA, 108, 60%; IB, 48, 27%; II, 14, 8%; III, 11, 6%). The 3- and 5-year RFS rates of patients with mutated or wild-type EGFR sequence were 79%, 68% and 77%, 68%, respectively (p=0.557). The respective OS rates were 92%, 81%, and 89%, 79% (p=0.574). CONCLUSION: Matched-pair and multi-institutional analysis reveals that an EGFR mutation was not a significant risk factor for recurrence of patients with surgically resected lung adenocarcinoma.
OBJECTIVE: It is unclear whether epidermal growth factor receptor (EGFR) mutation status is a risk factor for postoperative recurrence of surgically resected lung adenocarcinoma (ADC). Therefore, we conducted a multi-institutional study employing matched-pair analysis to compare recurrence-free survival (RFS) and overall survival (OS) of patients with lung ADC according to EGFR mutation status. METHODS: We collected the records of 909 patients who underwent surgical resection for lung ADC between 2005 and 2012 at five participating institutions and were also examined their EGFR mutation status. For each patient with an EGFR mutation, we selected one with the wild-type EGFR sequence and matched them according to institution, age, gender, smoking history, pathological stage (pStage), and adjuvant treatment. We compared RFS and OS of the matched cohort. RESULTS: The patients were allocated into groups (n=181 each) with mutated or wild-type EGFR sequences. Both cohorts had identical characteristics as follows: institution, median age (68 years), men (85, 47%), ever smokers (77, 43%), and pStage (IA, 108, 60%; IB, 48, 27%; II, 14, 8%; III, 11, 6%). The 3- and 5-year RFS rates of patients with mutated or wild-type EGFR sequence were 79%, 68% and 77%, 68%, respectively (p=0.557). The respective OS rates were 92%, 81%, and 89%, 79% (p=0.574). CONCLUSION: Matched-pair and multi-institutional analysis reveals that an EGFR mutation was not a significant risk factor for recurrence of patients with surgically resected lung adenocarcinoma.