Literature DB >> 29173752

Therapeutic Implications of the Genetic Landscape of Head and Neck Cancer.

Janice Cho1, Daniel E Johnson2, Jennifer R Grandis3.   

Abstract

Large-scale sequencing studies of head and neck squamous cell carcinoma (HNSCC) have elucidated the genetic changes that characterize HNSCC. These findings have supported the development of therapeutic strategies that target key components of aberrant signaling pathways and immune dysregulation. Cumulative evidence suggests that these agents in combination with radiotherapy may have synergistic effects. This review highlights the predictive biomarkers that have been identified from HNSCC genomic studies and implications on the development of molecular-targeting agents that may effectively treat patients with HNSCC, especially when used in combination with radiation.
Copyright © 2017 Elsevier Inc. All rights reserved.

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Year:  2018        PMID： 29173752      PMCID： PMC6293987          DOI： 10.1016/j.semradonc.2017.08.005

Source DB:  PubMed          Journal:  Semin Radiat Oncol        ISSN： 1053-4296            Impact factor:   5.934


  95 in total

Review 1.  Systematic review of dose--volume correlates for structures related to late swallowing disturbances after radiotherapy for head and neck cancer.

Authors:  Fréderic Duprez; Indira Madani; Bruno De Potter; Tom Boterberg; Wilfried De Neve
Journal:  Dysphagia       Date:  2013-02-22       Impact factor: 3.438

2.  Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas.

Authors:  Simon Papillon-Cavanagh; Chao Lu; Tenzin Gayden; Leonie G Mikael; Denise Bechet; Christina Karamboulas; Laurie Ailles; Jason Karamchandani; Dylan M Marchione; Benjamin A Garcia; Ilan Weinreb; David Goldstein; Peter W Lewis; Octavia Maria Dancu; Sandeep Dhaliwal; William Stecho; Christopher J Howlett; Joe S Mymryk; John W Barrett; Anthony C Nichols; C David Allis; Jacek Majewski; Nada Jabado
Journal:  Nat Genet       Date:  2017-01-09       Impact factor: 38.330

3.  Basal subtype is predictive for response to cetuximab treatment in patient-derived xenografts of squamous cell head and neck cancer.

Authors:  Konrad Klinghammer; Raik Otto; Jan-Dirk Raguse; Andreas E Albers; Ingeborg Tinhofer; Iduna Fichtner; Ulf Leser; Ulrich Keilholz; Jens Hoffmann
Journal:  Int J Cancer       Date:  2017-06-21       Impact factor: 7.396

Review 4.  Combination of radiotherapy and immune checkpoint inhibitors.

Authors:  Karsten A Pilones; Claire Vanpouille-Box; Sandra Demaria
Journal:  Semin Radiat Oncol       Date:  2015-01       Impact factor: 5.934

5.  Frequent mutation of the PI3K pathway in head and neck cancer defines predictive biomarkers.

Authors:  Vivian W Y Lui; Matthew L Hedberg; Hua Li; Bhavana S Vangara; Kelsey Pendleton; Yan Zeng; Yiling Lu; Qiuhong Zhang; Yu Du; Breean R Gilbert; Maria Freilino; Sam Sauerwein; Noah D Peyser; Dong Xiao; Brenda Diergaarde; Lin Wang; Simion Chiosea; Raja Seethala; Jonas T Johnson; Seungwon Kim; Umamaheswar Duvvuri; Robert L Ferris; Marjorie Romkes; Tomoko Nukui; Patrick Kwok-Shing Ng; Levi A Garraway; Peter S Hammerman; Gordon B Mills; Jennifer R Grandis
Journal:  Cancer Discov       Date:  2013-04-25       Impact factor: 39.397

Review 6.  Human papillomavirus and head and neck cancer.

Authors:  William M Mendenhall; Henrietta L C Logan
Journal:  Am J Clin Oncol       Date:  2009-10       Impact factor: 2.339

7.  Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor.

Authors:  A S Pak; M A Wright; J P Matthews; S L Collins; G J Petruzzelli; M R Young
Journal:  Clin Cancer Res       Date:  1995-01       Impact factor: 12.531

8.  PD-1-expressing tumor-infiltrating T cells are a favorable prognostic biomarker in HPV-associated head and neck cancer.

Authors:  Cécile Badoual; Stéphane Hans; Nathalie Merillon; Cordélia Van Ryswick; Patrice Ravel; Nadine Benhamouda; Emeline Levionnois; Mevyn Nizard; Ali Si-Mohamed; Nicolas Besnier; Alain Gey; Rinat Rotem-Yehudar; Hélène Pere; Thi Tran; Coralie L Guerin; Anne Chauvat; Estelle Dransart; Cécile Alanio; Sebastien Albert; Beatrix Barry; Federico Sandoval; Françoise Quintin-Colonna; Patrick Bruneval; Wolf H Fridman; Francois M Lemoine; Stephane Oudard; Ludger Johannes; Daniel Olive; Daniel Brasnu; Eric Tartour
Journal:  Cancer Res       Date:  2012-11-07       Impact factor: 12.701

9.  The CDK4/6 inhibitor LY2835219 has potent activity in combination with mTOR inhibitor in head and neck squamous cell carcinoma.

Authors:  Bo Mi Ku; Seong Yoon Yi; Jiae Koh; Yeon-Hee Bae; Jong-Mu Sun; Se-Hoon Lee; Jin Seok Ahn; Keunchil Park; Myung-Ju Ahn
Journal:  Oncotarget       Date:  2016-03-22

10.  Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer.

Authors:  Corina Lesseur; Brenda Diergaarde; Andrew F Olshan; Victor Wünsch-Filho; Andrew R Ness; Geoffrey Liu; Martin Lacko; José Eluf-Neto; Silvia Franceschi; Pagona Lagiou; Gary J Macfarlane; Lorenzo Richiardi; Stefania Boccia; Jerry Polesel; Kristina Kjaerheim; David Zaridze; Mattias Johansson; Ana M Menezes; Maria Paula Curado; Max Robinson; Wolfgang Ahrens; Cristina Canova; Ariana Znaor; Xavier Castellsagué; David I Conway; Ivana Holcátová; Dana Mates; Marta Vilensky; Claire M Healy; Neonila Szeszenia-Dąbrowska; Eleonóra Fabiánová; Jolanta Lissowska; Jennifer R Grandis; Mark C Weissler; Eloiza H Tajara; Fabio D Nunes; Marcos B de Carvalho; Steve Thomas; Rayjean J Hung; Wilbert H M Peters; Rolando Herrero; Gabriella Cadoni; H Bas Bueno-de-Mesquita; Annika Steffen; Antonio Agudo; Oxana Shangina; Xiangjun Xiao; Valérie Gaborieau; Amélie Chabrier; Devasena Anantharaman; Paolo Boffetta; Christopher I Amos; James D McKay; Paul Brennan
Journal:  Nat Genet       Date:  2016-10-17       Impact factor: 38.330
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  5 in total

1.  MicroRNA-Related Genetic Variants Associated with Survival of Head and Neck Squamous Cell Carcinoma.

Authors:  Owen M Wilkins; Alexander J Titus; Lucas A Salas; Jiang Gui; Melissa Eliot; Rondi A Butler; Erich M Sturgis; Guojun Li; Karl T Kelsey; Brock C Christensen
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2018-06-07       Impact factor: 4.254

2.  Gene alterations as predictors of radiation-induced toxicity in head and neck squamous cell carcinoma.

Authors:  Whitney Sumner; Xenia Ray; Leisa Sutton; Daniel Rebibo; Francesco Marincola; Parag Sanghvi; Vitali Moiseenko; Ida Deichaite
Journal:  J Transl Med       Date:  2021-05-17       Impact factor: 5.531

3.  Rh type C-glycoprotein functions as a novel tumor suppressor gene by inhibiting tumorigenicity and metastasis in head and neck squamous cell carcinoma.

Authors:  Wenguang Xu; Huihui Zou; Zheng Wei; Chuanhui Song; Chuanchao Tang; Xiteng Yin; Yufeng Wang; Shengwei Han; Yu Cai; Wei Han
Journal:  Aging (Albany NY)       Date:  2019-06-06       Impact factor: 5.682

4.  Recurrent copy number alterations involving EGFR, CDKN2A, and CCND1 in oral premalignant lesions.

Authors:  Fredrik Jäwert; André Fehr; Jenny Öhman; Göran Stenman; Göran Kjeller
Journal:  J Oral Pathol Med       Date:  2022-05-20       Impact factor: 3.539

5.  Genome-Wide Identification of a Novel Eight-lncRNA Signature to Improve Prognostic Prediction in Head and Neck Squamous Cell Carcinoma.

Authors:  Bowen Yang; Jiming Shen; Lu Xu; Ying Chen; Xiaofang Che; Xiujuan Qu; Yunpeng Liu; Yuee Teng; Zhi Li
Journal:  Front Oncol       Date:  2019-09-18       Impact factor: 6.244
  5 in total

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