Literature DB >> 2917337

Mechanism of i(6p) formation in retinoblastoma tumor cells.

B Horsthemke1, V Greger, R Becher, E Passarge.   

Abstract

Isochromosome (6p) represents a highly characteristic cytogenetic abnormality of human retinoblastoma (RB) cells and may be important for tumor progression. To elucidate the mechanism by which this abnormal chromosome is formed, 24 RB tumors and three cell lines were studied by means of DNA polymorphisms specific for the short arm and the long arm of chromosome 6. Our results indicate that mitotic nondisjunction leading to trisomy 6 precedes the isochromosome formation. The isochromosome may then be formed by transverse division of the centromere or intrachromosomal chromatid exchange.

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Year:  1989        PMID： 2917337     DOI： 10.1016/0165-4608(89)90079-4

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  4 in total

Review 1.  Chromosome 6p amplification and cancer progression.

Authors:  Gda C Santos; M Zielenska; M Prasad; J A Squire
Journal:  J Clin Pathol       Date:  2006-06-21       Impact factor: 3.411

2.  Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.

Authors:  B M Ghadimi; E Schröck; R L Walker; D Wangsa; A Jauho; P S Meltzer; T Ried
Journal:  Am J Pathol       Date:  1999-02       Impact factor: 4.307

3.  Concordance between parental origin of chromosome 13q loss and chromosome 6p duplication in sporadic retinoblastoma.

Authors:  A Naumova; M Hansen; L Strong; P A Jones; D Hadjistilianou; D Mastrangelo; S Griegel; M F Rajewsky; J Shields; L Donoso
Journal:  Am J Hum Genet       Date:  1994-02       Impact factor: 11.025

4.  Mutation spectrum of RB1 mutations in retinoblastoma cases from Singapore with implications for genetic management and counselling.

Authors:  Swati Tomar; Raman Sethi; Gangadhara Sundar; Thuan Chong Quah; Boon Long Quah; Poh San Lai
Journal:  PLoS One       Date:  2017-06-02       Impact factor: 3.240
  4 in total

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