Literature DB >> 29173166

Anticancer Potential of Thiazole Derivatives: A Retrospective Review.

Shweta Jain1, Satyanarayan Pattnaik2, Kamla Pathak2, Sushant Kumar2, Devender Pathak2, Surendra Jain3, Ankur Vaidya2.   

Abstract

This review brings forth the potential of thiazole derivatives for their anticancer activities. The emphasis is placed on the structural diversity of thiazole derivatives, responsible for their specific anticancer activity. Multiple classes of thiazole derivatives such as Schiff base, mono-, di-, tri-, and heterocyclic substituents that possess anticancer activity have been exemplified. Molecular modelling of compounds that predicts enhanced anticancer activity of the modified structures has also been elaborated in the review. Significant advancements in synthetic chemistry related to cytotoxicity can now better position the drug discovery team to undertake thiazoles as valuable leads. The beneficial thiazole derivatives possessing anticancer activity will reignite the interest of medicinal chemists in thiazole and their derivatives. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Entities:  

Keywords:  Anticancer; HIV; biological activity; structure-activity relationship; thiazole; thiazole derivatives.

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Substances：

Year:  2018        PMID： 29173166     DOI： 10.2174/1389557517666171123211321

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  5 in total

Review 1.  Synthesis of Biologically Active Molecules through Multicomponent Reactions.

Authors:  Daniel Insuasty; Juan Castillo; Diana Becerra; Hugo Rojas; Rodrigo Abonia
Journal:  Molecules       Date:  2020-01-24       Impact factor: 4.411

2.  Novel 2-(5-Aryl-4,5-Dihydropyrazol-1-yl)thiazol-4-One as EGFR Inhibitors: Synthesis, Biological Assessment and Molecular Docking Insights.

Authors:  Tarfah Al-Warhi; Ahmed M El Kerdawy; Mohamed A Said; Amgad Albohy; Zainab M Elsayed; Nada Aljaeed; Eslam B Elkaeed; Wagdy M Eldehna; Hatem A Abdel-Aziz; Miral A Abdelmoaz
Journal:  Drug Des Devel Ther       Date:  2022-05-16       Impact factor: 4.319

3.  Synthesis of Novel Aminothiazole Derivatives as Promising Antiviral, Antioxidant and Antibacterial Candidates.

Authors:  Rūta Minickaitė; Birutė Grybaitė; Rita Vaickelionienė; Povilas Kavaliauskas; Vidmantas Petraitis; Rūta Petraitienė; Ingrida Tumosienė; Ilona Jonuškienė; Vytautas Mickevičius
Journal:  Int J Mol Sci       Date:  2022-07-12       Impact factor: 6.208

4.  5-Benzyliden-2-(5-methylthiazol-2-ylimino)thiazolidin-4-ones as Antimicrobial Agents. Design, Synthesis, Biological Evaluation and Molecular Docking Studies.

Authors:  Michelyne Haroun; Christophe Tratrat; Aggeliki Kolokotroni; Anthi Petrou; Athina Geronikaki; Marija Ivanov; Marina Kostic; Marina Sokovic; Alejandro Carazo; Přemysl Mladěnka; Nagaraja Sreeharsha; Katharigatta N Venugopala; Anroop B Nair; Heba S Elsewedy
Journal:  Antibiotics (Basel)       Date:  2021-03-17

5.  Design, synthesis and biological evaluation of novel thiazole-naphthalene derivatives as potential anticancer agents and tubulin polymerisation inhibitors.

Authors:  Guangcheng Wang; Wenjing Liu; Meiyan Fan; Min He; Yongjun Li; Zhiyun Peng
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051
  5 in total

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