Ana Arpón1,2, Fermín I Milagro1,2,3, Ana Laja4, Víctor Segura5, Miguel Sáenz de Pipaón6,7,8, José-Ignacio Riezu-Boj1,2,9, J Alfredo Martínez1,2,3,9,10. 1. Department of Nutrition, Food Sciences & Physiology, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain. 2. Centre for Nutrition Research, Universidad de Navarra, Irunlarrea 1, 31008 Pamplona, Spain. 3. Spanish Biomedical Research Centre in Physiopathology of Obesity & Nutrition (CIBERobn), Institute of Health Carlos III, Madrid, Spain. 4. Department of Pharmaceutical & Health Sciences, Faculty of Pharmacy, CEU San Pablo University, Madrid, Spain. 5. Unit of Bioinformatics, Centre for Applied Medical Research (CIMA), Universidad de Navarra, Pamplona, Spain. 6. Neonatology Department, Hospital Universitario de la Paz, Madrid, Spain. 7. Instituto de Salud Carlos III, Red de Salud Materno Infantil y Desarrollo (SAMID), Madrid, Spain. 8. Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain. 9. Digestive disease and Nutrition group, Navarra Institute for Health Research (IdiSNa), Pamplona, Spain. 10. Madrid Institute of Advanced Studies (IMDEA), IMDEA Food, Madrid, Spain.
Abstract
AIM: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. PATIENTS & METHODS: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. RESULTS: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. CONCLUSION: SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.
AIM: To analyze whether preterm newborns show differences in methylation patterns in comparison to full-term newborns in white blood cells. PATIENTS & METHODS: Anthropometrical, biochemical features and methylation levels of preterm newborns (n = 24) and full-term newborns (n = 22) recruited in La Paz University Hospital (Spain) were assessed at 12 months of gestational age, whereas Bayley Scale of Infant Development was evaluated at 24/36 months. RESULTS: From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. CONCLUSION:SLC6A3 methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmental diseases in newborns.
Authors: Georgia Chalfun; Marcelo Martins Reis; Mariana Barros Genuíno de Oliveira; Aline de Araújo Brasil; Margarida Dos Santos Salú; Antônio José Ledo Alves da Cunha; Arnaldo Prata-Barbosa; Maria Clara de Magalhães-Barbosa Journal: Epigenetics Date: 2021-10-01 Impact factor: 4.861
Authors: Nienke H van Dokkum; Sofia Bachini; Rikst Nynke Verkaik-Schakel; Dyvonne H Baptist; Sahar Salavati; Karianne E Kraft; Sicco A Scherjon; Arend F Bos; Torsten Plösch Journal: Front Pediatr Date: 2022-06-01 Impact factor: 3.569
Authors: Arthur Sant'Anna Feltrin; Ana Carolina Tahira; Sérgio Nery Simões; Helena Brentani; David Corrêa Martins Journal: PLoS One Date: 2019-01-15 Impact factor: 3.240