Literature DB >> 29171997

Tau and Amyloid Positron Emission Tomography Imaging Predict Driving Performance Among Older Adults with and without Preclinical Alzheimer's Disease.

Catherine M Roe1,2, Ganesh M Babulal1,2, Shruti Mishra3, Brian A Gordon3, Sarah H Stout1,2, Brian R Ott4, David B Carr5, Beau M Ances2,3, John C Morris1,2,6,7,8,9,5,4, Tammie L S Benzinger1,3,10.   

Abstract

Abnormal levels of Alzheimer's disease (AD) biomarkers, measured by positron emission tomography imaging using amyloid-based radiotracers and cerebrospinal fluid, are associated with impaired driving performance in older adults. We examined whether preclinical AD staging, defined using amyloid imaging and tau imaging using the radiotracer T807 (AKA flortaucipir or AV-1451), was associated with receiving a marginal/fail rating on a standardized road test (n = 42). Participants at Stage 2 (positive amyloid and tau scans) of preclinical AD were more likely to receive a marginal/fail rating compared to participants at Stage 0 or 1. Stage 2 preclinical AD may manifest in worse driving performance.

Entities:  

Keywords:  Alzheimer’s disease; amyloid; driving performance; imaging; noncognitive outcomes; tau

Mesh：

Substances：

Year:  2018        PMID： 29171997      PMCID： PMC5784441          DOI： 10.3233/JAD-170521

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  30 in total

1.  Normative data stratified by age and education for two measures of verbal fluency: FAS and animal naming.

Authors:  T N Tombaugh; J Kozak; L Rees
Journal:  Arch Clin Neuropsychol       Date:  1999-02       Impact factor: 2.813

2.  Trail Making Test A and B: normative data stratified by age and education.

Authors:  Tom N Tombaugh
Journal:  Arch Clin Neuropsychol       Date:  2004-03       Impact factor: 2.813

3.  Preclinical Alzheimer's disease and its outcome: a longitudinal cohort study.

Authors:  Stephanie Jb Vos; Chengjie Xiong; Pieter Jelle Visser; Mateusz S Jasielec; Jason Hassenstab; Elizabeth A Grant; Nigel J Cairns; John C Morris; David M Holtzman; Anne M Fagan
Journal:  Lancet Neurol       Date:  2013-09-04       Impact factor: 44.182

4.  Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807.

Authors:  David T Chien; Shadfar Bahri; A Katrin Szardenings; Joseph C Walsh; Fanrong Mu; Min-Ying Su; William R Shankle; Arkadij Elizarov; Hartmuth C Kolb
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

5.  In vivo cortical spreading pattern of tau and amyloid in the Alzheimer disease spectrum.

Authors:  Hanna Cho; Jae Yong Choi; Mi Song Hwang; You Jin Kim; Hye Mi Lee; Hye Sun Lee; Jae Hoon Lee; Young Hoon Ryu; Myung Sik Lee; Chul Hyoung Lyoo
Journal:  Ann Neurol       Date:  2016-07-08       Impact factor: 10.422

6.  Predicting road test performance in drivers with dementia.

Authors:  David B Carr; Peggy P Barco; Michael J Wallendorf; Carol A Snellgrove; Brian R Ott
Journal:  J Am Geriatr Soc       Date:  2011-10-12       Impact factor: 5.562

7.  Partial volume correction in quantitative amyloid imaging.

Authors:  Yi Su; Tyler M Blazey; Abraham Z Snyder; Marcus E Raichle; Daniel S Marcus; Beau M Ances; Randall J Bateman; Nigel J Cairns; Patricia Aldea; Lisa Cash; Jon J Christensen; Karl Friedrichsen; Russ C Hornbeck; Angela M Farrar; Christopher J Owen; Richard Mayeux; Adam M Brickman; William Klunk; Julie C Price; Paul M Thompson; Bernadino Ghetti; Andrew J Saykin; Reisa A Sperling; Keith A Johnson; Peter R Schofield; Virginia Buckles; John C Morris; Tammie L S Benzinger
Journal:  Neuroimage       Date:  2014-12-05       Impact factor: 6.556

8.  Mild neuritic changes are increased in the brains of fatally injured older motor vehicle drivers.

Authors:  C A Gorrie; M Rodriguez; P Sachdev; J Duflou; P M E Waite
Journal:  Accid Anal Prev       Date:  2007-03-19

9.  Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake.

Authors:  Catherine M Roe; Mark A Mintun; Gina D'Angelo; Chengjie Xiong; Elizabeth A Grant; John C Morris
Journal:  Arch Neurol       Date:  2008-11

10.  Preclinical Alzheimer's disease and longitudinal driving decline.

Authors:  Catherine M Roe; Ganesh M Babulal; Denise M Head; Sarah H Stout; Elizabeth K Vernon; Nupur Ghoshal; Brad Garland; Peggy P Barco; Monique M Williams; Ann Johnson; Rebecca Fierberg; M Scot Fague; Chengjie Xiong; Elizabeth Mormino; Elizabeth A Grant; David M Holtzman; Tammie L S Benzinger; Anne M Fagan; Brian R Ott; David B Carr; John C Morris
Journal:  Alzheimers Dement (N Y)       Date:  2017-01
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  4 in total

1.  Using Naturalistic Driving Data to Predict Mild Cognitive Impairment and Dementia: Preliminary Findings from the Longitudinal Research on Aging Drivers (LongROAD) Study.

Authors:  Xuan Di; Rongye Shi; Carolyn DiGuiseppi; David W Eby; Linda L Hill; Thelma J Mielenz; Lisa J Molnar; David Strogatz; Howard F Andrews; Terry E Goldberg; Barbara H Lang; Minjae Kim; Guohua Li
Journal:  Geriatrics (Basel)       Date:  2021-04-23

2.  Using the A/T/N Framework to Examine Driving in Preclinical AD.

Authors:  Catherine M Roe; Ganesh M Babulal; Sarah H Stout; Brian R Ott; David B Carr; Monique M Williams; Tammie L S Benzinger; Anne M Fagan; David M Holtzman; Beau M Ances; John C Morris
Journal:  Geriatrics (Basel)       Date:  2018-05-02

Review 3.  Improving Our Understanding of Driving Changes in Preclinical and Early Symptomatic Alzheimer's Disease: The Role of Naturalistic Driving Studies.

Authors:  Catherine M Roe
Journal:  J Alzheimers Dis Rep       Date:  2022-08-11

Review 4.  Driving Ability in Alzheimer Disease Spectrum: Neural Basis, Assessment, and Potential Use of Optic Flow Event-Related Potentials.

Authors:  Takao Yamasaki; Shozo Tobimatsu
Journal:  Front Neurol       Date:  2018-09-07       Impact factor: 4.003
  4 in total

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