Joshua J Smith 1 , Daniel J Fletcher 1 , Stacy D Cooley 2 , Margret S Thompson 1 Show Affiliations »
Abstract
OBJECTIVE: To develop a reference range for ultrasonographically measured optic nerve sheath diameter (ONSD-US) in dogs. We hypothesized that ONSD-US can be measured reliably and is associated with weight but not age, sex, or body condition score (BCS), and that the relationship between weight and ONSD-US in dogs is allometric due to canine size variations. DESIGN: Prospective, observational study. SETTING: University teaching hospital. ANIMALS: Seventy-eight healthy adult dogs. INTERVENTIONS: The ONSD was measured by a standardized transpalpebral approach. MEASUREMENTS AND MAIN RESULTS: Regression analysis showed the relationship between weight and ONSD was better fit with a linear model (R2 = 0.8510) than an allometric model (R2 = 0.7917). Multiple regression analysis showed ONSD is associated with weight (P < 0.0001), age (P = 0.0021), and BCS (P = 0.0007), but not with sex. Dominance analysis showed 94.6% of the variance explained by the model was due to weight. Intraclass correlation coefficient (ICC) analysis showed excellent interobserver (ICC = 0.9338-0.9608) and intraobserver (ICC = 0.9893) reliability. CONCLUSIONS: These results suggest that ONSD-US may be reliably measured in dogs using our described transpalpebral approach, and we have calculated prediction intervals based on body weight. Future studies are needed to determine if ONSD-US measurements are associated with intracranial hypertension as shown in human medicine. © Veterinary Emergency and Critical Care Society 2017.
OBJECTIVE: To develop a reference range for ultrasonographically measured optic nerve sheath diameter (ONSD-US) in dogs . We hypothesized that ONSD-US can be measured reliably and is associated with weight but not age, sex, or body condition score (BCS), and that the relationship between weight and ONSD-US in dogs is allometric due to canine size variations. DESIGN: Prospective, observational study. SETTING: University teaching hospital. ANIMALS: Seventy-eight healthy adult dogs . INTERVENTIONS: The ONSD was measured by a standardized transpalpebral approach. MEASUREMENTS AND MAIN RESULTS: Regression analysis showed the relationship between weight and ONSD was better fit with a linear model (R2 = 0.8510) than an allometric model (R2 = 0.7917). Multiple regression analysis showed ONSD is associated with weight (P < 0.0001), age (P = 0.0021), and BCS (P = 0.0007), but not with sex. Dominance analysis showed 94.6% of the variance explained by the model was due to weight. Intraclass correlation coefficient (ICC) analysis showed excellent interobserver (ICC = 0.9338-0.9608) and intraobserver (ICC = 0.9893) reliability. CONCLUSIONS: These results suggest that ONSD-US may be reliably measured in dogs using our described transpalpebral approach, and we have calculated prediction intervals based on body weight. Future studies are needed to determine if ONSD-US measurements are associated with intracranial hypertension as shown in human medicine. © Veterinary Emergency and Critical Care Society 2017.
Entities: Disease
Species
Keywords:
assessment; intracranial hypertension; intracranial pressure
Mesh： See more »
Year: 2017
PMID： 29171933 DOI： 10.1111/vec.12677
Source DB: PubMed Journal: J Vet Emerg Crit Care (San Antonio) ISSN： 1476-4431