BACKGROUND: To identify strains of Mycobacterium tuberculosis complex (MTBc) circulating in Bamako region during the past 10 years. METHODS: From 2006 to 2016, we conducted a cross-sectional study to identify with spoligotyping, clinical isolates from tuberculosis (TB)-infected patients at different stages of their treatments in Bamako, Mali. RESULTS: Among the 904 suspected TB patients included in the study and thereafter tested in our BSL-3 laboratory, 492 (54.4%) had MTBc and therefore underwent spoligotyping. Overall, three subspecies, i.e., MTB T1 (31.9%) and MTB LAM10 (15.3%) from lineage 4 and M. africanum 2 (16.8%) from lineage 6 were the leading causes of TB in Bamako region during the past 10 years. Other spoligotypes such as MTB T3, MTB Haarlem 2, MTB EAI3, and MTB family 33 were also commonly seen from 2010 to 2016. CONCLUSION: This study showed a high genetic diversity of strains isolated in Bamako region and highlights that M. tuberculosis T1 strain was the most prevalent. Furthermore, the data indicate an increasing proportion of primary drug resistance overtime in Bamako.
BACKGROUND: To identify strains of Mycobacterium tuberculosis complex (MTBc) circulating in Bamako region during the past 10 years. METHODS: From 2006 to 2016, we conducted a cross-sectional study to identify with spoligotyping, clinical isolates from tuberculosis (TB)-infectedpatients at different stages of their treatments in Bamako, Mali. RESULTS: Among the 904 suspected TB patients included in the study and thereafter tested in our BSL-3 laboratory, 492 (54.4%) had MTBc and therefore underwent spoligotyping. Overall, three subspecies, i.e., MTB T1 (31.9%) and MTB LAM10 (15.3%) from lineage 4 and M. africanum 2 (16.8%) from lineage 6 were the leading causes of TB in Bamako region during the past 10 years. Other spoligotypes such as MTB T3, MTB Haarlem 2, MTB EAI3, and MTB family 33 were also commonly seen from 2010 to 2016. CONCLUSION: This study showed a high genetic diversity of strains isolated in Bamako region and highlights that M. tuberculosis T1 strain was the most prevalent. Furthermore, the data indicate an increasing proportion of primary drug resistance overtime in Bamako.
Authors: S Godreuil; G Torrea; D Terru; F Chevenet; S Diagbouga; P Supply; P Van de Perre; C Carriere; A L Bañuls Journal: J Clin Microbiol Date: 2007-01-24 Impact factor: 5.948
Authors: Kristin Kremer; Catherine Arnold; Angel Cataldi; M Cristina Gutiérrez; Walter H Haas; Stefan Panaiotov; Robin A Skuce; Philip Supply; Adri G M van der Zanden; Dick van Soolingen Journal: J Clin Microbiol Date: 2005-11 Impact factor: 5.948
Authors: B Traore; B Diarra; B P P Dembele; A M Somboro; A S Hammond; S Siddiqui; M Maiga; B Kone; Y S Sarro; J Washington; M Parta; N Coulibaly; O M'baye; S Diallo; O Koita; A Tounkara; M A Polis Journal: Int J Tuberc Lung Dis Date: 2012-04-09 Impact factor: 2.373
Authors: J Kamerbeek; L Schouls; A Kolk; M van Agterveld; D van Soolingen; S Kuijper; A Bunschoten; H Molhuizen; R Shaw; M Goyal; J van Embden Journal: J Clin Microbiol Date: 1997-04 Impact factor: 5.948
Authors: D Affolabi; G Anyo; F Faïhun; N Sanoussi; I C Shamputa; L Rigouts; L Kestens; S Anagonou; F Portaels Journal: Int J Tuberc Lung Dis Date: 2009-03 Impact factor: 2.373
Authors: Amadou Kone; Bassirou Diarra; Keira Cohen; Seydou Diabate; Bourahima Kone; Mahamane T Diakite; Hawa Diarra; Moumine Sanogo; Antieme C G Togo; Yeya Dit Sadio Sarro; Bocar Baya; Nadie Coulibaly; Ousmane Kodio; Chad J Achenbach; Robert L Murphy; Jane L Holl; Sophia Siddiqui; Seydou Doumbia; William R Bishai; Souleymane Diallo; Mamoudou Maiga Journal: HLA Date: 2019-01-02 Impact factor: 4.513
Authors: B Diarra; M Tolofoudie; Y S Sarro; A C G Togo; S Bane; I Nientao; A B Cisse; M Kone; A Somboro; B Degoga; F Diallo; G Coulibaly; O Kodio; M Sanogo; B Kone; S Diabate; B Baya; A Kone; D Dabitao; M Maiga; M Belson; S Dao; I I Maiga; R L Murphy; S Siddiqui; Y Toloba; B Konate; S Doumbia; B C de Jong; S Diallo Journal: J Clin Tuberc Other Mycobact Dis Date: 2019-11-01
Authors: Madikay Senghore; Bassirou Diarra; Florian Gehre; Jacob Otu; Archibald Worwui; Abdul Khalie Muhammad; Brenda Kwambana-Adams; Gemma L Kay; Moumine Sanogo; Bocar Baya; Susan Orsega; Seydou Doumbia; Souleymane Diallo; Bouke C de Jong; Mark J Pallen; Martin Antonio Journal: Sci Rep Date: 2020-01-15 Impact factor: 4.379