Literature DB >> 29171006

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy.

Jeannine Foley1, Veronica Burnham1, Meghan Tedoldi2, Nika N Danial2, Gary Yellen1.   

Abstract

Metabolic alteration, either through the ketogenic diet (KD) or by genetic alteration of the BAD protein, can produce seizure protection in acute chemoconvulsant models of epilepsy. To assess the seizure-protective role of knocking out (KO) the Bad gene in a chronic epilepsy model, we used the Kcna1-/- model of epilepsy, which displays progressively increased seizure severity and recapitulates the early death seen in sudden unexplained death in epilepsy (SUDEP). Beginning on postnatal day 24 (P24), we continuously video monitored Kcna1-/- and Kcna1-/- Bad-/- double knockout mice to assess survival and seizure severity. We found that Kcna1-/- Bad-/- mice outlived Kcna1-/- mice by approximately 2 weeks. Kcna1-/- Bad-/- mice also spent significantly less time in seizure than Kcna1-/- mice on P24 and the day of death, showing that BadKO provides seizure resistance in a genetic model of chronic epilepsy. Wiley Periodicals, Inc.
© 2017 International League Against Epilepsy.

Entities:  

Keywords:  zzm321990BADzzm321990; zzm321990Kcna1zzm321990−/−zzm321990; Kv1.1; metabolic seizure resistance

Mesh：

Substances：

Year:  2017        PMID： 29171006      PMCID： PMC5760331          DOI： 10.1111/epi.13960

Source DB:  PubMed          Journal:  Epilepsia        ISSN： 0013-9580            Impact factor:   5.864


  14 in total

1.  Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.

Authors:  Edward Glasscock; Jong W Yoo; Tim T Chen; Tara L Klassen; Jeffrey L Noebels
Journal:  J Neurosci       Date:  2010-04-14       Impact factor: 6.167

2.  Ketogenic diet treatment abolishes seizure periodicity and improves diurnal rhythmicity in epileptic Kcna1-null mice.

Authors:  Kristina A Fenoglio-Simeone; Julianne C Wilke; Heather L Milligan; Charles N Allen; Jong M Rho; Rama K Maganti
Journal:  Epilepsia       Date:  2009-06-01       Impact factor: 5.864

Review 3.  History of the ketogenic diet.

Authors:  James W Wheless
Journal:  Epilepsia       Date:  2008-11       Impact factor: 5.864

4.  Deletion of the K(V)1.1 potassium channel causes epilepsy in mice.

Authors:  S L Smart; V Lopantsev; C L Zhang; C A Robbins; H Wang; S Y Chiu; P A Schwartzkroin; A Messing; B L Tempel
Journal:  Neuron       Date:  1998-04       Impact factor: 17.173

5.  Ketone bodies mediate antiseizure effects through mitochondrial permeability transition.

Authors:  Do Young Kim; Kristina A Simeone; Timothy A Simeone; Jignesh D Pandya; Julianne C Wilke; Younghee Ahn; James W Geddes; Patrick G Sullivan; Jong M Rho
Journal:  Ann Neurol       Date:  2015-05-06       Impact factor: 10.422

6.  A novel mutation in the human voltage-gated potassium channel gene (Kv1.1) associates with episodic ataxia type 1 and sometimes with partial epilepsy.

Authors:  S M Zuberi; L H Eunson; A Spauschus; R De Silva; J Tolmie; N W Wood; R C McWilliam; J B Stephenson; J P Stephenson; D M Kullmann; M G Hanna
Journal:  Brain       Date:  1999-05       Impact factor: 13.501

7.  BAD-dependent regulation of fuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.

Authors:  Alfredo Giménez-Cassina; Juan Ramón Martínez-François; Jill K Fisher; Benjamin Szlyk; Klaudia Polak; Jessica Wiwczar; Geoffrey R Tanner; Andrew Lutas; Gary Yellen; Nika N Danial
Journal:  Neuron       Date:  2012-05-24       Impact factor: 17.173

Review 8.  The ketogenic diet: metabolic influences on brain excitability and epilepsy.

Authors:  Andrew Lutas; Gary Yellen
Journal:  Trends Neurosci       Date:  2012-12-08       Impact factor: 13.837

9.  Ketogenic diet treatment increases longevity in Kcna1-null mice, a model of sudden unexpected death in epilepsy.

Authors:  Kristina A Simeone; Stephanie A Matthews; Jong M Rho; Timothy A Simeone
Journal:  Epilepsia       Date:  2016-06-27       Impact factor: 5.864

Review 10.  How does the ketogenic diet induce anti-seizure effects?

Authors:  Jong M Rho
Journal:  Neurosci Lett       Date:  2015-07-26       Impact factor: 3.046
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  6 in total

1.  BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.

Authors:  John Maringa Githaka; Namita Tripathi; Raven Kirschenman; Namrata Patel; Vrajesh Pandya; David A Kramer; Rachel Montpetit; Lin Fu Zhu; Nahum Sonenberg; Richard P Fahlman; Nika N Danial; D Alan Underhill; Ing Swie Goping
Journal:  Nat Commun       Date:  2021-05-19       Impact factor: 14.919

2.  BAD and KATP channels regulate neuron excitability and epileptiform activity.

Authors:  Juan Ramón Martínez-François; María Carmen Fernández-Agüera; Nidhi Nathwani; Carolina Lahmann; Veronica L Burnham; Nika N Danial; Gary Yellen
Journal:  Elife       Date:  2018-01-25       Impact factor: 8.140

Review 3.  Clinical Spectrum of KCNA1 Mutations: New Insights into Episodic Ataxia and Epilepsy Comorbidity.

Authors:  Kelsey Paulhus; Lauren Ammerman; Edward Glasscock
Journal:  Int J Mol Sci       Date:  2020-04-17       Impact factor: 5.923

4.  Electrical Control in Neurons by the Ketogenic Diet.

Authors:  Nagisa Sada; Tsuyoshi Inoue
Journal:  Front Cell Neurosci       Date:  2018-07-16       Impact factor: 5.505

5.  BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages.

Authors:  Jie Li; Liansheng Zhang; Yongwei Zheng; Rui Shao; Qianqian Liang; Weida Yu; Hongyan Wang; Weiguo Zou; Demin Wang; Jialing Xiang; Anning Lin
Journal:  Elife       Date:  2020-12-03       Impact factor: 8.140

6.  Scurrying to Understand Sudden Expected Death in Epilepsy: Insights From Animal Models.

Authors:  Rui Li; Gordon F Buchanan
Journal:  Epilepsy Curr       Date:  2019-09-16       Impact factor: 7.500
  6 in total

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