| Literature DB >> 29170778 |
Mehdi Boudjemeline1, Christopher D McNitt, Thomas A Singleton, Vladimir V Popik, Alexey P Kostikov.
Abstract
A novel prosthetic group for the efficient radiolabeling of macromolecules has been developed. [18F]oxadibenzocyclooctyne ([18F]ODIBO) is synthesized in high radiochemical yield and applied for nearly quantitative conjugation to azide-tagged peptides and proteins at room temperature and low substrate concentrations. The resulting bioconjugates are chemically and radiochemically pure and free of toxic solvents and catalysts.Entities:
Mesh:
Substances:
Year: 2018 PMID: 29170778 PMCID: PMC5999037 DOI: 10.1039/c7ob02532g
Source DB: PubMed Journal: Org Biomol Chem ISSN: 1477-0520 Impact factor: 3.876